TNS sodium
Based on 1 publication(s) in Google Scholar
TNS (6-(p-Tolylamino) naphthalene-2-sulfonate) sodium is a fluorescent probe used to detect the conformational state of proteins. TNS sodium binds to the central hydrophobic calyx of β-lactoglobulin (β-LG) to form a 1:1 complex, which stabilizes the folded conformation of β-LG. TNS sodium shows weak fluorescent signals in aqueous solution, but its fluorescence intensity increases significantly upon binding to the hydrophobic domains of proteins, with the maximum excitation wavelength and maximum emission wavelength located at 321 nm and 446 nm, respectively.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 53313-85-2
- Formula: C17H14NNaO3S
- Molecular Weight:335.36
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) TNS sodium
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Biological Activity
TNS (10 μM TNS, 10 μM β-LG; 298 K) sodium binds to purified bovine β-lactoglobulin (β-LG) at a distance of 2.5 nm from the Trp19 residue of β-LG at pH 7.0[1].
TNS (sodium) (25 μM TNS, 25 μM β-LG; incubated with 0-1.2 M NaCl) binding to purified bovine β-lactoglobulin (β-LG) at pH 7.0 is disrupted by increasing ionic strength (via NaCl), with the most significant disruption occurring at NaCl concentrations between 0 M and 0.25 M[1].
TNS (10 μM TNS, 10 μM β-LG; 20 min) sodium binding to purified bovine β-lactoglobulin (β-LG) at pH 7.0 stabilizes its fold, increasing the guanidine hydrochloride concentration required for unfolding from a midpoint of 2.3 M to 3.9 M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 53313-85-2
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Appearance Solid
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Molecular Weight 335.36
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Formula C17H14NNaO3S
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Color White to off-white
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SMILES
O=S(C1=CC=C2C=C(NC3=CC=C(C)C=C3)C=CC2=C1)(O[Na])=O
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Synonyms
6-(p-Tolylamino)naphthalene-2-sulfonate sodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Am Chem Soc
Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing. [Abstract]2026 Mar 11;148(9):10225-10240. PMID: 41733506
Solvent & Solubility
DMSO : 4 mg/mL (11.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9819 mL | 14.9094 mL | 29.8187 mL | 74.5468 mL |
| 5 mM | 0.5964 mL | 2.9819 mL | 5.9637 mL | 14.9094 mL | |
| 10 mM | 0.2982 mL | 1.4909 mL | 2.9819 mL | 7.4547 mL |
TNS sodium Related Classifications
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