1. Phenylpropanoids

Droxidopa (Synonyms: L-DOPS; DOPS; SM5688)

Cat. No.: HY-13458 Purity: 99.58%
Handling Instructions

Droxidopa(L-DOPS, SM5688) is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); capable of crossing the protective blood–brain barrier IC50 value: Target: The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow [1].

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Droxidopa Chemical Structure

Droxidopa Chemical Structure

CAS No. : 23651-95-8

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100 mg USD 168 In-stock
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Estimated Time of Arrival: December 31
500 mg USD 504 In-stock
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Estimated Time of Arrival: December 31
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  • Biological Activity

  • Protocol

  • Technical Information

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  • References

Description

Droxidopa(L-DOPS, SM5688) is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline); capable of crossing the protective blood–brain barrier IC50 value: Target: The acute administration of droxidopa in PVL and BDL rats caused a significant and maintained increase in arterial pressure and mesenteric arterial resistance, with a significant decrease of mesenteric arterial and portal blood flow, without changing portal pressure and renal blood flow [1]. L-threo-dihydroxyphenyslerine (Droxidopa) is a pro-drug which has a structure similar to noradrenaline, but with a carboxyl group. It has no pressor effects in this form. It can be administered orally, unlike noradrenaline, and after absorption is converted by the enzyme dopa decarboxylase into noradrenaline thus increasing levels of the neurotransmitter which is identical to endogenous noradrenaline [2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 1.8 mg/mL (8.44 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6907 mL 23.4533 mL 46.9065 mL
5 mM 0.9381 mL 4.6907 mL 9.3813 mL
10 mM 0.4691 mL 2.3453 mL 4.6907 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

213.19

Formula

C₉H₁₁NO₅

CAS No.

23651-95-8

SMILES

OC1=C(O)C=CC([[email protected]@H](O)[[email protected]@H](C(O)=O)N)=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Droxidopa
Cat. No.:
HY-13458
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Droxidopa

Cat. No.: HY-13458