ENTPD1 - ectonucleoside triphosphate diphosphohydrolase 1 Gene

Also Known as CD39; SPG64; ATPDase; NTPDase-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 953

About ENTPD1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:95,694,186-95,877,266 (from NCBI)

This gene has 13 transcripts (splice variants), 199 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in urinary bladder (RPKM 6.1), appendix (RPKM 5.8) and 24 other tissues.

Summary

The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer Anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

ENTPD1 Products (9)

mRNA	Protein	Name
NM_001098175.2	NP_001091645.1	ectonucleoside triphosphate diphosphohydrolase 1 isoform 2
NM_001164178.1	NP_001157650.1	ectonucleoside triphosphate diphosphohydrolase 1 isoform 3
NM_001164179.2	NP_001157651.1	ectonucleoside triphosphate diphosphohydrolase 1 isoform 4
NM_001164181.1	NP_001157653.1	ectonucleoside triphosphate diphosphohydrolase 1 isoform 5
NM_001164182.2	NP_001157654.1	ectonucleoside triphosphate diphosphohydrolase 1 isoform 6
NM_001164183.2	NP_001157655.1	ectonucleoside triphosphate diphosphohydrolase 1 isoform 6
NM_001312654.1	NP_001299583.1	ectonucleoside triphosphate diphosphohydrolase 1 isoform 5
NM_001320916.1	NP_001307845.1	ectonucleoside triphosphate diphosphohydrolase 1 isoform 7
NM_001776.6	NP_001767.3	ectonucleoside triphosphate diphosphohydrolase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nucleoside diphosphate phosphatase activity	IDA IDA: Inferred from direct assay	8529670	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16478441	GOA
enables ribonucleoside triphosphate phosphatase activity	IDA IDA: Inferred from direct assay	8529670	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in platelet aggregation	IMP IMP: Inferred from mutant phenotype	8955160	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in caveola	IDA IDA: Inferred from direct assay	10636909	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10636909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTPD1 Protein Structure

GDA1_CD39

0
100
200
300
400
510 a.a.

Protein Preferred Names	Protein Names
ectonucleoside triphosphate diphosphohydrolase 1	CD39 antigen

ENTPD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ENTPD1	P49961	RANBP9	Homo sapiens	Q96S59	Y2H	16478441

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ENTPD1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75417	CD39 Protein, Human (sf9, His)	P49961 (T38-V478)	≥ 90%, as determined by reducing SDS-PAGE.

ENTPD1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81349	CD39 Antibody (YA1094)	IHC-P	Human
HY-P81349A	CD39 Antibody (YA1094)(PBS only)	IHC-P	Human
HY-P84363	CD39 Antibody (YA4060)	WB, ELISA	Human
HY-P84363A	CD39 Antibody (YA4060)(PBS only)	WB, ELISA	Human
HY-P84993	CD39 Antibody (YA4685)	ELISA	Human

Related Diseases

Diseases	Alias
Spastic Paraplegia 64, Autosomal Recessive	SPG64 Hereditary Spastic Paraplegia 64 Autosomal Recessive Spastic Paraplegia Type 64 Autosomal Recessive Spastic Paraplegia 64 Paraplegia, Spastic, Type 64, Autosomal Recessive
Thrombosis	Thrombosis Of Blood Vessel
Beta-Thalassemia	Beta Thalassemia Cooley'S Anemia Mediterranean Anemia Beta Thalassemia Intermedia Erythroblastic Anemia Thalassemia, Hispanic Gamma-Delta-Beta Thalassemia Major Thalassemia Minor Beta-Plus-Thalassemia Thalassemia, Beta Beta Thalassemia Major Beta Thalassemia Minor Thalassemias, Beta- Microcytemia, Beta Type Thalassemia, Beta Type B-THAL Mediterranean Anaemia Beta Thalassaemia Syndrome Mediterranean Disease Beta Thalassaemia Disease
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Calcification Of Joints And Arteries	Hereditary Arterial And Articular Multiple Calcification Syndrome CALJA Arterial Calcification Due To Cd73 Deficiency Arterial Calcification Due To Deficiency Of Cd73 Acdc Arterial Calcification And Distal Joint Calcification Arterial Calcification Due To Deficiency Of Cd73:Acdc Calcification Of Joints And Arteries Calja
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked	IPEX X-Linked Autoimmunity-Allergic Dysregulation Syndrome Xlaad Diarrhea, Polyendocrinopathy, Fatal Infection Syndrome, X-Linked Ipex Syndrome Insulin-Dependent Diabetes Mellitus Secretory Diarrhea Syndrome Iddm-Secretory Diarrhea Syndrome Dmsd Autoimmunity-Immunodeficiency Syndrome, X-Linked Enteropathy, Autoimmune, With Hemolytic Anemia And Polyendocrinopathy Xpid Diabetes Mellitus, Congenital Insulin-Dependent, With Fatal Secretory Diarrhea Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome Polyendocrinopathy, Immune Dysfunction, And Diarrhea, X-Linked Autoimmune Enteropathy Type 1 Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked Immunodeficiency, Polyendocrinopathy, And Enteropathy, X-Linked, Formerly Immunodeficiency, Polyendocrinopathy, Enteropathy X-Linked Syndrome Immunodysregulation, Polyendocrinopathy And Enteropathy X-Linked Autoimmunity-Immunodeficiency Syndrome X-Linked Iddm Secretory Diarrhea Syndrome Polyendocrinopathy, Immune Dysfunction And Diarrhea X-Linked Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-Linked Syndrome Immunodeficiency Polyendocrinopathy, Enteropathy, X-Linked Syndrome X-Linked Autoimmunity-Immunodeficiency Syndrome Immunodeficiency, Polyendocrinopathy, And Enteropathy X-Linked Syndrome X-Linked Syndrome Of Polyendocrinopathy, Immune Dysfunction, And Diarrhea
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Dermatitis, Atopic, 7	ATOD7 Dermatitis, Atopic, Susceptibility To, 7 Atopic Dermatitis 7 Dermatitis, Atopic 7
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990068	Perenostobart	Inhibitor	97.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04395	ENTPD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18563	Entpd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25045	Entpd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992099	Afivastobart	Inhibitor	99.36%	Unkown
HY-P991701	Mebarase alfa	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ENTPD1	VGNC	VGNC:59064
Bos taurus	ENTPD1	VGNC	VGNC:97269
Rattus norvegicus	ENTPD1	RGD	RGD:69265
Mus musculus	ENTPD1	MGD	MGI:102805
Felis catus	ENTPD1	VGNC	VGNC:97418
Others	ENTPD1	NCBI