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Cat. No.: HY-117744

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NMS-P645

NMS-P645 is a PIM1 inhibitor. NMS-P645 exhibits anti-proliferative activity when combined with GDC-0941 (HY-50094) in TMPRSS2/ERG positive and negative PCa cells. NMS-P645 can reverse PIM1-induced pro-survival signals in prostate cells. NMS-P645 can be studied in research on prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 1482518-95-5
Formula: C₂₈H₃₈ClN₅O₂
Molecular Weight:512.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

NMS-P645 Chemical Structure

CAS No.: 1482518-95-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Pim Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	>10 μM Compound: 15a	Cytotoxicity against mouse BA/F3 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against mouse BA/F3 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
BaF3	IC₅₀	0.125 μM Compound: 15a	Cytotoxicity against mouse BA/F3 cells overexpressing PIM1 after 72 hrs by CellTitre-Glo assay Cytotoxicity against mouse BA/F3 cells overexpressing PIM1 after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
CAPAN-1	IC₅₀	3.704 μM Compound: 15a	Cytotoxicity against human Capan1 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human Capan1 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
KMS-11	IC₅₀	7.134 μM Compound: 15a	Cytotoxicity against human KMS11 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human KMS11 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
LNCaP	IC₅₀	3.313 μM Compound: 15a	Cytotoxicity against human LNCAP cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human LNCAP cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
LP-1	IC₅₀	1.929 μM Compound: 15a	Cytotoxicity against human LP-1 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human LP-1 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
MV4-11	IC₅₀	1.529 μM Compound: 15a	Cytotoxicity against human MV4-11 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human MV4-11 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
NCI-H929	IC₅₀	5.928 μM Compound: 15a	Cytotoxicity against human NCI-H929 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human NCI-H929 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]
RPMI-8226	IC₅₀	6.658 μM Compound: 15a	Cytotoxicity against human RPMI8226 cells after 72 hrs by CellTitre-Glo assay Cytotoxicity against human RPMI8226 cells after 72 hrs by CellTitre-Glo assay	[PMID: 24139169]

Chemical Information

CAS No. 1482518-95-5
Molecular Weight 512.09
Formula C₂₈H₃₈ClN₅O₂
SMILES

O=C(N[C@@H](C1CCCCC1)CN2CCN(C)CC2)C[C@H]3CNC(C4=CC(C5=CC=CC(Cl)=C5)=CN43)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Mologni, L., et al., (2017). The Novel PIM1 Inhibitor NMS-P645 Reverses PIM1-Dependent Effects on TMPRSS2/ERG Positive Prostate Cancer Cells And Shows Anti-Proliferative Activity in Combination with PI3K Inhibition. Journal of Cancer, 8(1), 140-145. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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NMS-P645

All Pim Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NMS-P645 Related Classifications

HY-117744 Related Classifications