Pentetic acid
Based on 3 publication(s) in Google Scholar
Pentetic acid (Diethylenetriaminepentaacetic acid) is an orally active compound with biodegradability used to construct magnetic adsorbent, which can simultaneously remove heavy metal and dye from complex wastewater. Pentetic acid can form strong metal complexes, which prevents metal ions from catalysing the decomposition of peroxygen chemicals, especially hydrogen peroxide.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 67-43-6
- Formula: C14H23N3O10
- Molecular Weight:393.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pentetic acid
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
264.5 μM
Compound: DTPA
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Cytotoxicity against human HeLa cells after 72 hrs by MTS assay
Cytotoxicity against human HeLa cells after 72 hrs by MTS assay
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[PMID: 18345610] |
| HepG2 | IC50 |
38.3 μM
Compound: DTPA
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 29233652] |
| HT-29 | IC50 |
39.1 μM
Compound: DTPA
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Cytotoxicity against human HT29 cells after 72 hrs by MTS assay
Cytotoxicity against human HT29 cells after 72 hrs by MTS assay
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[PMID: 18345610] |
Pentetic acid (0-100 μM, 16 h) inhibits the secretion of elastase in PAO1 cells[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PAO1
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Concentration:10, 50, 100 μM
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Incubation Time:16 h
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Result:Decreased the expression of lasB gene transcription levels.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 67-43-6
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Appearance Solid
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Molecular Weight 393.35
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Formula C14H23N3O10
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Color White to off-white
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SMILES
O=C(O)CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O
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Synonyms
Diethylenetriaminepentaacetic acid; DTPA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (3)
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Journal Impact Factor
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Most Recent
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Adv Healthc Mater
Oral Administration of Trifluoroacetyl Chitosan-Encapsulated Redshifted Immunofluorophore for NIR-II Bioimaging of Colorectal Metastases. [Abstract]2025 Oct 15:e01877. PMID: 41097850 -
Solvent & Solubility
DMSO : 5 mg/mL (12.71 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Huang Y, et al. Enhanced selective adsorption of lead(II) from complex wastewater by DTPA functionalized chitosan-coated magnetic silica nanoparticles based on anion-synergism. J Hazard Mater. 2022;422:126856. [Content Brief]
[3]. Metsärinne S, et al. Biological and photochemical degradation rates of diethylenetriaminepentaacetic acid (DTPA) in the presence and absence of Fe(III). Chemosphere. 2004 Apr;55(3):379-88. [Content Brief]
[4]. FOREMAN H. The effect of diethylenetriaminepentaacetic acid (DTPA) on acceleration of excretion of actinide elements. Health Phys. 1962 Dec;8:735-7. [Content Brief]
[5]. Gi M, et al. A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2014 Dec;58(12):7205-14. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5423 mL | 12.7113 mL | 25.4227 mL | 63.5566 mL |
| 5 mM | 0.5085 mL | 2.5423 mL | 5.0845 mL | 12.7113 mL | |
| 10 mM | 0.2542 mL | 1.2711 mL | 2.5423 mL | 6.3557 mL |
Pentetic acid Related Classifications
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