Anavenol
Based on 1 Customer Validation
Anavenol (β-Naphthoxyethanol) is an anesthetic. Anavenol exerts anesthetic effects on horses. Anavenol can be used in studies on adverse events associated with equine anesthesia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.14%
- No. CAS: 93-20-9
- Fòrmula: C12H12O2
- Peso molecular:188.22
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Thoroughbred (geldings, mares, colts; 3-year-old, 6-year-old; ~900 lbs, ~925 lbs)[2]
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Dosage:100 c.c. (fatal reaction); 250 c.c. (life-threatening reaction)
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Administration:over 120 seconds for 100 c.c.
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Result:Caused sudden collapse, severe cardiovascular and respiratory distress, and death in a healthy 3-year-old colt despite 20 minutes of intravenous cardiac stimulation and artificial respiration.
Caused severe cardiovascular and respiratory reactions, requiring intravenous cardiac stimulation; tricuspid regurgitation followed post-procedure in a 6-year-old mare.
Resulted in unpredictable anesthesia depth despite identical weight/condition in other thoroughbreds.
Triggered alarming cardiovascular/respiratory symptoms in multiple cases, some requiring supportive interventions.
Chemical Information
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No. CAS 93-20-9
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Appearance Solid
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Peso molecular 188.22
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Fòrmula C12H12O2
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Color White to off-white
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SMILES
OCCOC1=CC2=CC=CC=C2C=C1
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Synonyms
β-Naphthoxyethanol
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 200 mg/mL (1062.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (26.56 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.3129 mL | 26.5647 mL | 53.1293 mL | 132.8233 mL |
| 5 mM | 1.0626 mL | 5.3129 mL | 10.6259 mL | 26.5647 mL | |
| 10 mM | 0.5313 mL | 2.6565 mL | 5.3129 mL | 13.2823 mL | |
| 15 mM | 0.3542 mL | 1.7710 mL | 3.5420 mL | 8.8549 mL | |
| 20 mM | 0.2656 mL | 1.3282 mL | 2.6565 mL | 6.6412 mL | |
| 25 mM | 0.2125 mL | 1.0626 mL | 2.1252 mL | 5.3129 mL | |
| 30 mM | 0.1771 mL | 0.8855 mL | 1.7710 mL | 4.4274 mL | |
| 40 mM | 0.1328 mL | 0.6641 mL | 1.3282 mL | 3.3206 mL | |
| 50 mM | 0.1063 mL | 0.5313 mL | 1.0626 mL | 2.6565 mL | |
| 60 mM | 0.0885 mL | 0.4427 mL | 0.8855 mL | 2.2137 mL | |
| 80 mM | 0.0664 mL | 0.3321 mL | 0.6641 mL | 1.6603 mL | |
| 100 mM | 0.0531 mL | 0.2656 mL | 0.5313 mL | 1.3282 mL |
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