CBR Agonist-1
CBR Agonist-1 (27a-cis) is a cannabinoid receptor (CBR) agonist with the Ki values of 0.18 μM for CB1R and 1.22 μM for CB2R. CBR Agonist-1 (27a-cis) can be used in the study of endogenous cannabinoid system-related diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C27H27FN4O
- Peso molecular:442.53
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
rCB1-R 0.18 μM (Ki) |
hCB2-R 1.22 μM (Ki) |
CBR Agonist-1 (27a-cis) (24 h) can activate GRABeCB2.0 (fluorescent CB1R sensor) in a concentration-dependent manner with the EC50 value of 2.1 μM in HEK293T cell lines[1].
CBR Agonist-1 (27a-cis) (0-10 mM) acts on hCB1R calcium mobilization with the IC50 value of 3.10 μM in overexpressed hCB1R CHO-K1cells[1].
CBR Agonist-1 (27a-cis) (10-1000 nM, 15 min) induces increased phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) in a dose-dependent manner in expressed Gαq16 and hCB1 CHO cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Peso molecular 442.53
-
Fòrmula C27H27FN4O
-
SMILES
O=C(C1=CN(C2=CC=CC=C12)CCCCCF)NCC3=CC=CC=C3/N=N\C4=CC=CC=C4
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBR Agonist-1 Related Classifications
HY-151105 Related Classifications
Powered by Bioz