FYCO1 - FYVE and coiled-coil domain autophagy adaptor 1 Gene

Also Known as CATC2; RUFY3; ZFYVE7; CTRCT18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79443

About FYCO1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,917,903-45,995,824 (from NCBI)

This gene has 5 transcripts (splice variants), 286 orthologues, 1 paralogue and is associated with 5 phenotypes. Ubiquitous expression in heart (RPKM 22.7), endometrium (RPKM 12.6) and 25 other tissues.

Summary

The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the Kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020]

FYCO1 Products (11)

mRNA	Protein	Name
NM_001386421.1	NP_001373350.1	FYVE and coiled-coil domain-containing protein 1 isoform 1
NM_001386422.1	NP_001373351.1	FYVE and coiled-coil domain-containing protein 1 isoform 1
NM_001386423.1	NP_001373352.1	FYVE and coiled-coil domain-containing protein 1 isoform 2
NM_001386424.1	NP_001373353.1	FYVE and coiled-coil domain-containing protein 1 isoform 3
NM_001386425.1	NP_001373354.1	FYVE and coiled-coil domain-containing protein 1 isoform 4
NM_001386426.1	NP_001373355.1	FYVE and coiled-coil domain-containing protein 1 isoform 5
NM_001386427.1	NP_001373356.1	FYVE and coiled-coil domain-containing protein 1 isoform 6
NM_001386428.1	NP_001373357.1	FYVE and coiled-coil domain-containing protein 1 isoform 7
NM_001386429.1	NP_001373358.1	FYVE and coiled-coil domain-containing protein 1 isoform 8
NM_001386430.1	NP_001373359.1	FYVE and coiled-coil domain-containing protein 1 isoform 9
NM_024513.4	NP_078789.2	FYVE and coiled-coil domain-containing protein 1 isoform 1

FYCO1 Protein Structure

RUN

FYVE

0
300
600
900
1200
1478 a.a.

Protein Preferred Names	Protein Names
FYVE and coiled-coil domain-containing protein 1	FYVE and coiled-coil domain containing 1

FYCO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Cross	FYCO1	Q9BQS8	P0DTD1-PRO_0000449630	SARS-CoV-2	P0DTD1-PRO_0000449630	Y2H Array	36217030
Intra	FYCO1	Q9BQS8	MAP1LC3C	Homo sapiens	Q9BXW4	Pull Down	20562859
Intra	FYCO1	Q9BQS8	KIF5B	Homo sapiens	P33176	Pull Down	25855459
Intra	FYCO1	Q9BQS8	KIF5B	Homo sapiens	P33176	Anti Tag CoIP	25855459
Intra	FYCO1	Q9BQS8	KIF5B	Homo sapiens	P33176	Anti Tag CoIP	20562859
Intra	FYCO1	Q9BQS8	MAP1LC3B	Homo sapiens	Q9GZQ8	Pull Down	20562859
Intra	FYCO1	Q9BQS8	KDM1A	Homo sapiens	O60341	Y2H	23455924
Intra	FYCO1	Q9BQS8	GABARAP	Homo sapiens	O95166	Pull Down	20562859
Intra	FYCO1	Q9BQS8	GABARAPL2	Homo sapiens	P60520	Pull Down	20562859
Intra	FYCO1	Q9BQS8	KLC2	Homo sapiens	Q9H0B6	Pull Down	25855459
Intra	FYCO1	Q9BQS8	GABARAPL1	Homo sapiens	Q9H0R8	Pull Down	20562859
Intra	FYCO1	Q9BQS8	PRMT6	Homo sapiens	Q96LA8	Y2H	23455924
Intra	FYCO1	Q9BQS8	PRMT6	Homo sapiens	Q96LA8	Anti Tag CoIP	23455924

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cataract 18	Cataract, Autosomal Recessive Congenital 2 Catc2 CTRCT18 Autosomal Recessive Congenital Cataract 2 Cataract 18, Autosomal Recessive Cataract 18 Autosomal Recessive Cataract, Type 18
Cataract 44	CTRCT44 Total Early-Onset Cataract Cataract 44 And Hypotrichosis Cataract And Hypotrichosis Cataract, Type 44
Early-Onset Nuclear Cataract
Inclusion Body Myositis	Ibm Sporadic Inclusion Body Myositis Inflammatory Myopathy Myositis, Inclusion Body Inflammatory Myopathies Sibm Myositis Inclusion Body Nonaka Myopathy Inclusion Body Myopathy, Autosomal Recessive Inclusion Body Myopathy, Autosomal Dominant Myositis Inclusion Body Myopathy, Sporadic
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Myositis	Idiopathic Inflammatory Myopathy Idiopathic Inflammatory Myositis Iim Imm Idiopathic Inflammatory Myopathies Myopathy, Familial Idiopathic Inflammatory Inflammatory Disorder Of Muscle Idiopathic Inflammatory Myopathy, Familial Inflammatory Myopathy, Idiopathic Myopathies Idiopathic Inflammatory Familial Idiopathic Inflammatory Myopathy
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Deprivation Amblyopia	Disuse Amblyopia Stimulus Deprivation Amblyopia
Combined Cellular And Humoral Immune Defects With Granulomas	Combined Immunodeficiency With Skin Granulomas CCHIDG Cid Due To Rag 1/2 Deficiency Combined Immunodeficiency Due To Rag 1/2 Deficiency Combined Immunodeficiency With Granulomatosis CHIDG Immune Defects, Combined Cellular And Humoral With Granulomas
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS05173	FYCO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FYCO1	VGNC	VGNC:72722
Felis catus	FYCO1	VGNC	VGNC:80049
Rattus norvegicus	FYCO1	RGD	RGD:1309069
Canis familiaris	FYCO1	VGNC	VGNC:41026
Bos taurus	FYCO1	VGNC	VGNC:29162
Mus musculus	FYCO1	MGD	MGI:107277
Others	FYCO1	NCBI