FYCO1 - FYVE and coiled-coil domain autophagy adaptor 1 Gene

Also Known as CATC2; RUFY3; ZFYVE7; CTRCT18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79443

About FYCO1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:45,917,903-45,995,824 (from NCBI)

This gene has 5 transcripts (splice variants), 286 orthologues, 1 paralogue and is associated with 5 phenotypes. Ubiquitous expression in heart (RPKM 22.7), endometrium (RPKM 12.6) and 25 other tissues.

Summary

The gene encodes a Rab7 adapter protein that is implicated in the microtubule transport of autophagosomes. The encoded protein contains a RUN domain, a FYVE-type zinc finger domain, and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P), the autophagosome marker LC3, and the Kinesin KIF5. Mutations in this gene are associated with inclusion body myositis (IBM) and autosomal recessive congenital cataracts (CATC2). [provided by RefSeq, Aug 2020]

FYCO1 Products (11)

mRNA Protein Name
NM_001386421.1 NP_001373350.1 FYVE and coiled-coil domain-containing protein 1 isoform 1
NM_001386422.1 NP_001373351.1 FYVE and coiled-coil domain-containing protein 1 isoform 1
NM_001386423.1 NP_001373352.1 FYVE and coiled-coil domain-containing protein 1 isoform 2
NM_001386424.1 NP_001373353.1 FYVE and coiled-coil domain-containing protein 1 isoform 3
NM_001386425.1 NP_001373354.1 FYVE and coiled-coil domain-containing protein 1 isoform 4
NM_001386426.1 NP_001373355.1 FYVE and coiled-coil domain-containing protein 1 isoform 5
NM_001386427.1 NP_001373356.1 FYVE and coiled-coil domain-containing protein 1 isoform 6
NM_001386428.1 NP_001373357.1 FYVE and coiled-coil domain-containing protein 1 isoform 7
NM_001386429.1 NP_001373358.1 FYVE and coiled-coil domain-containing protein 1 isoform 8
NM_001386430.1 NP_001373359.1 FYVE and coiled-coil domain-containing protein 1 isoform 9
NM_024513.4 NP_078789.2 FYVE and coiled-coil domain-containing protein 1 isoform 1

FYCO1 Protein Structure

RUN

RUN: RUN domain (60 - 165)

FYVE

FYVE: FYVE zinc finger (1169 - 1231)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1478 a.a.
Protein Preferred Names Protein Names

FYVE and coiled-coil domain-containing protein 1

  • FYVE and coiled-coil domain containing 1

FYCO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
FYCO1 Q9BQS8 P0DTD1-PRO_0000449630 SARS-CoV-2 P0DTD1-PRO_0000449630 36217030
Intra
FYCO1 Q9BQS8 MAP1LC3C Homo sapiens Q9BXW4 20562859
Intra
FYCO1 Q9BQS8 KIF5B Homo sapiens P33176 25855459
Intra
FYCO1 Q9BQS8 KIF5B Homo sapiens P33176 25855459
Intra
FYCO1 Q9BQS8 KIF5B Homo sapiens P33176 20562859
Intra
FYCO1 Q9BQS8 MAP1LC3B Homo sapiens Q9GZQ8 20562859
Intra
FYCO1 Q9BQS8 KDM1A Homo sapiens O60341
Y2H
23455924
Intra
FYCO1 Q9BQS8 GABARAP Homo sapiens O95166 20562859
Intra
FYCO1 Q9BQS8 GABARAPL2 Homo sapiens P60520 20562859
Intra
FYCO1 Q9BQS8 KLC2 Homo sapiens Q9H0B6 25855459
Intra
FYCO1 Q9BQS8 GABARAPL1 Homo sapiens Q9H0R8 20562859
Intra
FYCO1 Q9BQS8 PRMT6 Homo sapiens Q96LA8
Y2H
23455924
Intra
FYCO1 Q9BQS8 PRMT6 Homo sapiens Q96LA8 23455924
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cataract 18
  • Cataract, Autosomal Recessive Congenital 2

  • Catc2

  • CTRCT18

  • Autosomal Recessive Congenital Cataract 2

  • Cataract 18, Autosomal Recessive

  • Cataract 18 Autosomal Recessive

  • Cataract, Type 18

Cataract 44
  • CTRCT44

  • Total Early-Onset Cataract

  • Cataract 44 And Hypotrichosis

  • Cataract And Hypotrichosis

  • Cataract, Type 44

Early-Onset Nuclear Cataract
Inclusion Body Myositis
  • Ibm

  • Sporadic Inclusion Body Myositis

  • Inflammatory Myopathy

  • Myositis, Inclusion Body

  • Inflammatory Myopathies

  • Sibm

  • Myositis Inclusion Body

  • Nonaka Myopathy

  • Inclusion Body Myopathy, Autosomal Recessive

  • Inclusion Body Myopathy, Autosomal Dominant

  • Myositis

  • Inclusion Body Myopathy, Sporadic

Eye Disease
  • Eye Diseases

  • Abnormality Of The Eye

  • Toxoplasma Oculopathy

Myositis
  • Idiopathic Inflammatory Myopathy

  • Idiopathic Inflammatory Myositis

  • Iim

  • Imm

  • Idiopathic Inflammatory Myopathies

  • Myopathy, Familial Idiopathic Inflammatory

  • Inflammatory Disorder Of Muscle

  • Idiopathic Inflammatory Myopathy, Familial

  • Inflammatory Myopathy, Idiopathic

  • Myopathies Idiopathic Inflammatory

  • Familial Idiopathic Inflammatory Myopathy

Cataract
  • Cataracts

  • Cat - [Cataract]

  • Cataract Form

  • Lens Opacity

  • Lens Opacities

Deprivation Amblyopia
  • Disuse Amblyopia

  • Stimulus Deprivation Amblyopia

Combined Cellular And Humoral Immune Defects With Granulomas
  • Combined Immunodeficiency With Skin Granulomas

  • CCHIDG

  • Cid Due To Rag 1/2 Deficiency

  • Combined Immunodeficiency Due To Rag 1/2 Deficiency

  • Combined Immunodeficiency With Granulomatosis

  • CHIDG

  • Immune Defects, Combined Cellular And Humoral With Granulomas

Amyotrophic Lateral Sclerosis 1
  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive
  • Charcot-Marie-Tooth Disease Type 4

  • Charcot-Marie-Tooth Disease Type 4e

  • Hereditary Motor And Sensory Neuropathy

  • Cmt4e

  • CHN1

  • Hypomyelinating Neuropathy, Congenital, 1

  • Charcot-Marie-Tooth Neuropathy Type 4e

  • Neuropathy, Congenital Hypomyelinating, 1

  • Ar-Cmt1

  • Autosomal Recessive Demyelinating Charcot-Marie-Tooth

  • Cmt4

  • Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive

  • Hypomyelination, Severe Congenital

  • Charcot-Marie-Tooth Disease, Type 4e

  • Charcot-Marie-Tooth Neuropathy, Type 4e

  • Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy

  • Autosomal Recessive Congenital Hypomyelinating Neuropathy

  • Congenital Amyelinating Neuropathy

  • Congenital Hypomyelinating Neuropathy Autosomal Recessive

  • Neuropathy, Congenital Hypomyelinating Or Amyelinating

  • Severe Congenital Hypomyelination

  • Hereditary Sensory Motor Neuropathy

  • Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive

  • Neuropathy, Hypomyelinating, Congenital, Type 1

  • Neuropathy, Motor And Sensory, Hereditary

  • Congenital Hypomyelinating Neuropathy

  • Hereditary Motor And Sensory Neuropathies

  • Hereditary Sensorimotor Neuropathy

  • Hmsn - [Hereditary Motor And Sensory Neuropathy]

  • Hsmn - [Hereditary Sensory And Motor Neuropathy]

  • Hereditary Motor And Sensory Neuropathy, Types I-Iv

Hereditary Spastic Paraplegia
  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta FYCO1 VGNC VGNC:72722
Felis catus FYCO1 VGNC VGNC:80049
Rattus norvegicus FYCO1 RGD RGD:1309069
Canis familiaris FYCO1 VGNC VGNC:41026
Bos taurus FYCO1 VGNC VGNC:29162
Mus musculus FYCO1 MGD MGI:107277
Others FYCO1 NCBI