MuRF1-IN-1
Based on 1 Customer Validation
MuRF1-IN-1 is an orally active MuRF1 inhibitor. MuRF1-IN-1 can inhibit the interaction between MuRF1 and titin as well as E3 ligase activity. MuRF1-IN-1 can alleviate skeletal muscle atrophy and dysfunction in cardiac cachexia.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.18%
- No. CAS: 445222-91-3
- Fòrmula: C18H15N3O3
- Peso molecular:321.33
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
Metabolism/Protease Compound Library
HY-L012
-
Covalent Screening Library
HY-L036
-
Oxygen Sensing Compound Library
HY-L045
-
Ubiquitination Compound Library
HY-L050
-
Orally Active Compound Library
HY-L061
-
Targeted Diversity Library
HY-L099
-
Metabolic Enzyme Compound Library
HY-L146
-
Cysteine Targeted Covalent Library
HY-L153
-
Mitophagy Compound Library
HY-L180
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Covalent Screening Library Plus
HY-L036P
-
Bioactive Compound Library
HY-L001
-
Amino Acid Metabolism Compound Library
HY-L189
-
Cell Proliferation Compound Library
HY-L201
-
High-Throughput Bioactive Compound Library
HY-L205
-
Posttranslational Modification Library
HY-L226
Actividad biológica
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| U-87MG ATCC | IC50 |
78 μg/mL
Compound: 6a
|
Cytotoxicity against Homo sapiens (human) U87 cells by MTT assay
Cytotoxicity against Homo sapiens (human) U87 cells by MTT assay
|
10.1007/s00044-012-0249-x |
MuRF1-IN-1 (Compound 704946) (0.1-10 µM; 26 h) inhibits Dexamethasone (HY-14648)-induced MuRF1 mRNA upregulation and completely prevents myofiber atrophy in C2C12 myotubes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Dexamethasone (HY-14648) treate C2C12 cells
-
Concentration:0.1 and 10 µM
-
Incubation Time:Pretreated with 2 h, then co-incubation for 24 h
-
Result:Reduced MuRF1 mRNA levels at 10 μM, but not 0.1 μM.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 mice aged 8 weeks old treated monocrotaline (HY-N0750) to induce cardiac cachexia[1]
-
Dosage:0.1% w/w
-
Administration:Dietary administration; 7 weeks
-
Result:Prevented atrophy in tibialis anterior (TA) muscle, with preserved wet weight and fibre cross-sectional area (CSA) compared to monocrotaline-treated controls. Wet weights of extensor digitorum longus (EDL) and soleus muscles were normalized to sham levels.
Restored diaphragm muscle shortening velocity and power to sham levels, reversing the ~20% impairment induced by cardiac cachexia.
Downregulated MuRF1 protein expression, normalized pro-apoptotic protein BAX and translation initiation factor eIF2B-δ, and attenuated actin ubiquitination and proteasome activity.
Chemical Information
-
No. CAS 445222-91-3
-
Appearance Solid
-
Peso molecular 321.33
-
Fòrmula C18H15N3O3
-
Color Off-white to gray
-
SMILES
N#CC1=C(N)OC(CCCC2=O)=C2C13C(N(C)C4=C3C=CC=C4)=O
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 125 mg/mL (389.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (285 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1121 mL | 15.5603 mL | 31.1207 mL | 77.8016 mL |
| 5 mM | 0.6224 mL | 3.1121 mL | 6.2241 mL | 15.5603 mL | |
| 10 mM | 0.3112 mL | 1.5560 mL | 3.1121 mL | 7.7802 mL | |
| 15 mM | 0.2075 mL | 1.0374 mL | 2.0747 mL | 5.1868 mL | |
| 20 mM | 0.1556 mL | 0.7780 mL | 1.5560 mL | 3.8901 mL | |
| 25 mM | 0.1245 mL | 0.6224 mL | 1.2448 mL | 3.1121 mL | |
| 30 mM | 0.1037 mL | 0.5187 mL | 1.0374 mL | 2.5934 mL | |
| 40 mM | 0.0778 mL | 0.3890 mL | 0.7780 mL | 1.9450 mL | |
| 50 mM | 0.0622 mL | 0.3112 mL | 0.6224 mL | 1.5560 mL | |
| 60 mM | 0.0519 mL | 0.2593 mL | 0.5187 mL | 1.2967 mL | |
| 80 mM | 0.0389 mL | 0.1945 mL | 0.3890 mL | 0.9725 mL | |
| 100 mM | 0.0311 mL | 0.1556 mL | 0.3112 mL | 0.7780 mL |
MuRF1-IN-1 Related Classifications
HY-129531 Related Classifications
Powered by Bioz