445222-91-3
445222-91-3
Chemical Structure
MuRF1-IN-1
- CAS No.: 445222-91-3
- Formula:C18H15N3O3
- Molecular Weight:321.33
IUPAC Name: 2-amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile
InChIKey: VXTHFLXWLSPJSP-UHFFFAOYSA-N
SMILES: N#CC1=C(N)OC(CCCC2=O)=C2C13C(N(C)C4=C3C=CC=C4)=O
Biological Activity: MuRF1-IN-1 is an orally active MuRF1 inhibitor. MuRF1-IN-1 can inhibit the interaction between MuRF1 and titin as well as E3 ligase activity. MuRF1-IN-1 can alleviate skeletal muscle atrophy and dysfunction in cardiac cachexia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MuRF1-IN-1 | 98.18% | MuRF1-IN-1 is an orally active MuRF1 inhibitor. MuRF1-IN-1 can inhibit the interaction between MuRF1 and titin as well as E3 ligase activity. MuRF1-IN-1 can alleviate skeletal muscle atrophy and dysfunction in cardiac cachexia. | ||||||||||||||||||||
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Rankinidine | Rankinidine is an oxindole alkaloid that is isolated from the MeOH extract of the stem of Gelsemium rankinii. | |||||||||||||||||||||
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UCPH-102 | 99.20% | UCPH-102 is a highly selective EAAT1 inhibitor with an IC50 of 0.43 µM. UCPH-102 exhibits a specific anti-proliferative effect on T-ALL cells. UCPH-102 also shows good blood-brain permeability, which can be used in studies of amyotrophic lateral sclerosis, Alzheimer’s disease, chronic pain and obsessive compulsive disorder. | ||||||||||||||||||||
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PPI-GIT1/β-Pix PPI-IN-1 | 99.01% | PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer. | ||||||||||||||||||||
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16-Methoxystrychnine | 16-Methoxystrychnine is a alkaloid. | |||||||||||||||||||||
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Vomicine | 99.85% | Vomicine modulates cGAS-STING-TBK1 signaling pathway, and exhibits anti-inflammatory activity. Vomicine is an alkaloid that can be isolated from Strychnos nux-vomica seeds. | ||||||||||||||||||||
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N1-Methoxymethyl picrinine | N1-Methoxymethyl picrinine (compound 3) is an indole alkaloid that can be isolated from the leaves of Alstonia scholaris. | |||||||||||||||||||||
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Gelsevirine | 98.80% | Gelsevirine is the major alkaloid in Gelsemium elegans with potent anxiolytic effects. The anxiolytic mechanism of Gelsevirine may be involved in the agonist action of the glycine receptor in the brain. Gelsevirine has anti-proliferation activity with IC50 values of 1.41 mM and 1.22 mM for SW480 cells and MGC80-3 cells, respectively. | ||||||||||||||||||||
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Humantenine | 98% | Humantenine is a highly toxic indole alkaloid from Gelsemium elegans (Gardn. & Champ.) Benth. that binds to RNA m6A modification regulatory proteins (ALKBH5, METTL). Humantenine stably binds via hydrogen bonding and hydrophobic interactions and disrupts the m6A methylation level of target genes, thereby impairing the expression of intestinal epithelial cell tight junction and cytoskeleton-related genes, causing intestinal barrier dysfunction and significant intestinal cytotoxicity. The intraperitoneal injection LD50 values of Humantenine are <1 mg/kg in mice, 1.2 mg/kg in male rats and 1.5 mg/kg in female rats, respectively. Species differences exist in the metabolism of Humantenine in human, porcine, goat and rat liver microsomes, and demethylation, dehydrogenation and oxidation occur in liver microsomes. | ||||||||||||||||||||
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Kopsine | Kopsine is an alkaloid that can be isolated from the medicinal psyllid. | |||||||||||||||||||||
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