2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR3-IN-5

FGFR3-IN-5 

Cat. No.: HY-148779
Handling Instructions

FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer.

For research use only. We do not sell to patients.

FGFR3-IN-5 Chemical Structure

FGFR3-IN-5 Chemical Structure

CAS No. : 2446664-72-6

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Description

FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].

IC50 & Target[1]

FGFR3

3 nM (IC50)

FGFR2

44 nM (IC50)

FGFR1

289 nM (IC50)

In Vitro

FGFR3-IN-5 (compound 37; 5 mM; 1 h; HEK-293 cells) inhibits FGFR phosphorylation with IC50 values of 8 and 59 nM for FGFR3 and FGFR1, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

477.49

Formula

C24H24FN7O3
CAS No.
SMILES

N#CC1=C2C(OC)=CC(C3=CN(C4CCN(CC4)C(C5(CN(C5)C(C=C)=O)F)=O)N=C3)=CN2N=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

FGFR3-IN-52446664-72-6FGFRFibroblast growth factor receptorFGFR phosphorylationcancerFGFR tyrosine kinasesInhibitorinhibitorinhibit

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