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Cat. No.: HY-152861

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Dazostinag

(Synonyms: TAK-676 free base)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Dazostinag (TAK-676 free base) is an agonist of stimulator of interferon genes (STING) protein with antineoplastic activity. Dazostinag can serve as a playload to synthesis antibody-drug conjugates (ADCs).

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CAS No.: 2553413-86-6
Formule: C₂₁H₂₂F₂N₈O₁₀P₂S₂
Masse moléculaire:710.52

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Dazostinag Chemical Structure

CAS No.: 2553413-86-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- In Vitro
- In Vivo
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Publications (1)
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Description

In Vitro

Dazostinag (ADC-1, linker-payload) (121 μM; 10 min-24 hr) exhibits an half-life (t_1/2) of 2.4 hr in rat liver tritosomes^[1].
Dazostinag (ADC-1, linker-payload) activates human Guanylyl cyclase C (GCC) with an EC₅₀ value of 0.068 nM in THPl cells with R232 variant of human STING^[1].
Dazostinag (ADC-1) (10 μg/mL; 0-96 hr) shows plasma stability in human, primate and mouse plasma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dazostinag (ADC-1) (0.1 mg/kg; single dose) shows an half-life of 33 h and the AUC (last) value of 51432 h·nM in Balb/C mice bearing CT26-GCC tumors^[1].
Dazostinag (ADC-1) (50 μg/kg, 100 μg/kg; i.v.; single dose, monitored for 2 weeks) significantly inhibits the growth of tumor in Balb/C mouse bearing GCC-expressing CT26 colon carcinoma mouse tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

CT26 colon carcinoma model in female Balb/C mice (6-8 weeks old)^[1]
Dosage:

50 μg/kg, 100 μg/kg
Administration:

IP; single dose, monitored for 15 days, measured two times per week
Result:

Significantly suppressed the volume of tumor in mice.

Chemical Information

CAS No. 2553413-86-6
Masse moléculaire 710.52
Formule C₂₁H₂₂F₂N₈O₁₀P₂S₂
SMILES

FC1=CN([C@H]2[C@H](O[P@@](OC[C@@H]3[C@@H](O4)[C@@H](F)[C@H](N5C6=NC=NC(N)=C6N=C5)O3)(S)=O)[C@H](O)[C@@H](COP4(S)=O)O2)C7=C1C(N=CN7)=O
Synonyms

TAK-676 free base
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Science

Intermetallic nanoassemblies potentiate systemic STING activation. [Abstract]

2026 May 7;392(6798):eadx1893. PMID: 42096576

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ishii Yumiko, et al. Antibody drug conjugates comprising STING modulators: World Intellectual Property Organization, WO2020229982. 2020-11-19.

[2]. WHO Drug Information-World Health Organization (WHO).

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Dazostinag

1 Cited Publications

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Dazostinag

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