Dazostinag disodium
Based on 1 publication(s) in Google Scholar
Dazostinag disodium (TAK-676) is an agonist of STING, triggering the activation of STING signaling pathway and type I interferons. Dazostinag disodium is also a modulator of immune system, resulting complete regressions and durable memory T-cell immunity. Dazostinag disodium promotes durable IFN-dependent antitumor immunity.
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- Reinheit: 98.65%
- CAS. Nr.: 2553413-93-5
- Formel: C21H20F2N8Na2O10P2S2
- Molecular Weight:754.48
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dazostinag disodium
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Biologische Aktivität
STING, Type I interferons[1]
Dazostinag disodium (1.1, 3.3, and 10 μM; 2 h) dose-dependently activates the STING-TBK1-IRF3 pathway in THP1-Dual human AML cells and CT26.WT cells, but is critically dependent on STING expression[1].
Dazostinag disodium (0-1 μM; 24 h) exerts in vitro immune cell activation function in mouse BM-derived dendritic cells in a dose-dependent manner[1].
Dazostinag disodium (0-1 μM; 24 h) promotes the activation of dendritic cells (DC), natural killer (NK) cells, and T cells, with activation EC50s of 1.27 μM (MoDC), 0.32 μM (BMDC), 0.271 μM (NK), 0.216 μM (CD8+), 0.249 μM (CD4+) at 24 h, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP1-Dual human AML cells and CT26.WT cells
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Concentration:1.1, 3.3, 10 μM
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Incubation Time:2 hours
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Result:Increased pTBK1, pSTING, pIRF3 protein level in a dose-dependent manner.
Not induced the phosphorylation of pTBK1 (S172) or pIRF3 (S396) in the absence of STING expression.
Dazostinag disodium (1 mg/kg/d, 2 mg/kg/d; i.v.; 13 d) shows anti-tumor function on BALB/c mice bearing A20 syngeneic tumors/CT26.WT syngeneic tumors mode[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice bearing A20 syngeneic tumors/CT26.WT syngeneic tumors model[1]
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Dosage:1 or 2 mg/kg/day
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Administration:Intravenous injection; for 3, 6, 9, 12 day, respectively
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Result:Resulted in significant T cell–dependent in vivo antitumor activity.
Induced dose-dependent cytokine responses and increased the activation and proliferation of immune cells within the TME and tumor-associated lymphoid tissue.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 2553413-93-5
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Appearance Solid
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Molecular Weight 754.48
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Formel C21H20F2N8Na2O10P2S2
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Color White to off-white
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SMILES
FC1=CN([C@H]2[C@H](O[P@@](OC[C@@H]3[C@@H](O4)[C@@H](F)[C@H](N5C6=NC=NC(N)=C6N=C5)O3)([S-])=O)[C@H](O)[C@@H](COP4([S-])=O)O2)C7=C1C(N=CN7)=O.[Na+].[Na+]
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Synonyms
TAK-676
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Science
2026 May 7;392(6798):eadx1893. PMID: 42096576
Lösungsmittel & Löslichkeit
H2O : ≥ 100 mg/mL (132.54 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.3254 mL | 6.6271 mL | 13.2542 mL | 33.1354 mL |
| 5 mM | 0.2651 mL | 1.3254 mL | 2.6508 mL | 6.6271 mL | |
| 10 mM | 0.1325 mL | 0.6627 mL | 1.3254 mL | 3.3135 mL | |
| 15 mM | 0.0884 mL | 0.4418 mL | 0.8836 mL | 2.2090 mL | |
| 20 mM | 0.0663 mL | 0.3314 mL | 0.6627 mL | 1.6568 mL | |
| 25 mM | 0.0530 mL | 0.2651 mL | 0.5302 mL | 1.3254 mL | |
| 30 mM | 0.0442 mL | 0.2209 mL | 0.4418 mL | 1.1045 mL | |
| 40 mM | 0.0331 mL | 0.1657 mL | 0.3314 mL | 0.8284 mL | |
| 50 mM | 0.0265 mL | 0.1325 mL | 0.2651 mL | 0.6627 mL | |
| 60 mM | 0.0221 mL | 0.1105 mL | 0.2209 mL | 0.5523 mL | |
| 80 mM | 0.0166 mL | 0.0828 mL | 0.1657 mL | 0.4142 mL | |
| 100 mM | 0.0133 mL | 0.0663 mL | 0.1325 mL | 0.3314 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Dazostinag disodium Related Classifications
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