FXR agonist 16
FXR agonist 16 is a FXR agonist with an EC50 of 2.2 μM. FXR agonist 16 activates FXR transcriptional activity, upregulates SHP and BSEP, and downregulates Cyp7a1. FXR agonist 16 exhibits hepatoprotective activity and reduces AST and ALT levels in free fatty acid-induced hepatocellular injury models. FXR agonist 16 can be used for the research of liver injury.
For research use only. We do not sell to patients.
- CAS No.: 3099198-78-1
- Formula: C23H32O2S
- Molecular Weight:372.56
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
FXR agonist 16 (Compound 3q) (10-100 μM; 24 h) acts as a FXR agonist in stably transfected HEK293 cells, with an EC50 of 2.2 μM[1].
FXR agonist 16 (1-20 μM; 24 h) exhibits hepatoprotective activity in FFA-injured AML12 cells, reducing liver injury markers without obvious cytotoxicity at concentrations up to 25 μM[1].
FXR agonist 16 (1-10 μM) modulates FXR downstream target gene expression in AML12 cells, upregulating SHP and BSEP while downregulating Cyp7a1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:FFA-injured AML12 cells
-
Concentration:1, 10, 20 μM
-
Incubation Time:24 h
-
Result:Lowered both AST and ALT levels.
Chemical Information
-
CAS No. 3099198-78-1
-
Molecular Weight 372.56
-
Formula C23H32O2S
-
SMILES
CC1(C)[C@]2([H])CC[C@]3(C)CCC[C@](C3)(SC4=C(C(OC)=O)C=CC=C4)[C@@]2([H])C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz