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Cat. No.: HY-120667

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DS-5272

DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC₅₀ of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC₅₀=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice.

For research use only. We do not sell to patients.

CAS No.: 1235575-97-9
Formula: C₃₄H₃₈Cl₂F₂N₆O₂S
Molecular Weight:703.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

DS-5272 Chemical Structure

CAS No.: 1235575-97-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 20 nM (p53-MDM2 interaction)

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	GI₅₀	>50 μM Compound: 8, DS-5272	Antiproliferative activity against human DLD1 cells expressing mutant p53 after 3 days by luminescent cell viability assay Antiproliferative activity against human DLD1 cells expressing mutant p53 after 3 days by luminescent cell viability assay	[PMID: 25882531]
SJSA-1	GI₅₀	0.17 μM Compound: 8, DS-5272	Antiproliferative activity against human SJSA1 cells expressing wildtype p53 after 3 days by luminescent cell viability assay Antiproliferative activity against human SJSA1 cells expressing wildtype p53 after 3 days by luminescent cell viability assay	[PMID: 25882531]

Chemical Information

CAS No. 1235575-97-9
Molecular Weight 703.67
Formula C₃₄H₃₈Cl₂F₂N₆O₂S
SMILES

O=C([C@H]1N(C(C2=C(C(C)C)N3C(S2)=N[C@@](C)(C4=CC=C(Cl)N=C4)[C@H]3C5=CC=C(Cl)C(F)=C5)=O)C[C@H](F)C1)N(C6)[C@H](CC)CNC76CC7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miyazaki M, et al., Discovery of DS-5272 as a promising candidate: A potent and orally active p53-MDM2 interaction inhibitor. Bioorg Med Chem. 2015 May 15;23(10):2360-7. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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