1235575-97-9
Chemical Structure
DS-5272
- CAS No.: 1235575-97-9
- Formula:C34H38Cl2F2N6O2S
- Molecular Weight:703.67
IUPAC Name: ((5R,6S)-5-(4-chloro-3-fluorophenyl)-6-(6-chloropyridin-3-yl)-3-isopropyl-6-methyl-5,6-dihydroimidazo[2,1-b]thiazol-2-yl)((2S,4R)-2-((R)-6-ethyl-4,7-diazaspiro[2.5]octane-7-carbonyl)-4-fluoropyrrolidin-1-yl)methanone
InChIKey: QUYOIFDRHGZSFZ-YABFKZQLSA-N
SMILES: O=C([C@H]1N(C(C2=C(C(C)C)N3C(S2)=N[C@@](C)(C4=CC=C(Cl)N=C4)[C@H]3C5=CC=C(Cl)C(F)=C5)=O)C[C@H](F)C1)N(C6)[C@H](CC)CNC76CC7
Biological Activity: DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice[1].
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DS-5272 | DS-5272 is an orally acitve inhibitor for p53-MDM2 with an IC50 of 20 nM. DS-5272 inhibits the proliferation of SJSA-1 (wildtype p53, IC50=0.17 μM) and DLD-1 (mutant p53). DS-5272 arrest the cell cycle, and induces apoptosis in SJSA-1. DS-5272 exhibits antitumor efficacy in mice. | |||||||||||||||||||||
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Keywords
