FTO ligand-1
FTO ligand-1 is a FTO ligand for FTO PROTAC degrader FP54 (HY-175885). FTO ligand-1 can inhibit cell proliferation and block the FP54-induced FTO degradation. FTO ligand-1 can be used for research of cancer, such as acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- Formula: C27H30Cl2N4O5
- Molecular Weight:561.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
FTO ligand-1 shows anti-proliferative activity in NB4 cells with an EC50 of 19 μM[1].
FTO ligand-1 (0.4-10 μM, 2 h) dose-dependently blocks the FP54 (HY-175885)-induced FTO degradation in NB4 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NB4 cells
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Concentration:0.4, 2 and 10 μM, companied with FP54 (HY-175885) (2 μM)
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Incubation Time:2 h
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Result:Dose-dependently blocked the FP54 (HY-175885)-induced FTO degradation.
Chemical Information
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Molecular Weight 561.46
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Formula C27H30Cl2N4O5
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SMILES
ClC1=C(NC2=CC=CC(N3CCNCC3)=C2C(OCOC(C(C)C)=O)=O)C(Cl)=CC(C4=C(C)ON=C4C)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTO ligand-1 Related Classifications
HY-175886 Related Classifications
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