Ptgds - prostaglandin D2 synthase Gene

Also Known as PH2DISO

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25526

Summary

Enables prostaglandin-D synthase activity and retinoid binding activity. Involved in prostaglandin biosynthetic process and response to glucocorticoid. Located in Golgi apparatus and extracellular space. Biomarker of sensorineural hearing loss and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PTGDS (prostaglandin D2 synthase). [provided by Alliance of Genome Resources, Apr 2022]

Ptgds Products (1)

mRNA Protein Name
NM_013015.2 NP_037147.1 prostaglandin-H2 D-isomerase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables prostaglandin-D synthase activity IDA
IDA: Inferred from direct assay
7836410 RGD
enables retinoid binding IDA
IDA: Inferred from direct assay
9188476 RGD
Biological Process GO Annotation Evidence References Source
involved in prostaglandin biosynthetic process IDA
IDA: Inferred from direct assay
7836410 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
14618091 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11058225 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
8815894 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17259069 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin-H2 D-isomerase

  • PGD2 synthase

  • PGDS

  • PGDS2

  • Prostaglandin D synthase

  • glutathione-independent PGD synthase

  • glutathione-independent PGD synthetase

  • lipocalin-type prostaglandin-D synthase

  • prostaglandin D2 synthase (brain)

Recombinant Ptgds Proteins

Cat. No. Product Name Accession Purity
HY-P73709 PGD2 Synthase/PTGDS Protein, Rat (HEK293, His) P22057/NP_037147.1 (Q25-E189) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11374 PTGDS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18401 Ptgds Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24882 Ptgds Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptgds NCBI NCBI:5730