PTGDS - prostaglandin D2 synthase Gene

Homo sapiens

Also known as PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS

Gene ID: 5730 | Gene type: protein coding

About PTGDS

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,977,504-136,981,742 (from NCBI)

This gene has 10 transcripts (splice variants), 161 orthologues and 12 paralogues. Biased expression in testis (RPKM 1025.8), heart (RPKM 481.7) and 13 other tissues.

Summary

The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

PTGDS Products(1)

mRNA	Protein	Name
NM_000954.6	NP_000945.3	prostaglandin-H2 D-isomerase precursor

PTGDS Protein Structure

Lipocalin

0
100
190 a.a.

Protein Preferred Names

Protein Names

prostaglandin-H2 D-isomerase

PGD2 synthase

Recombinant PTGDS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71242	PTGDS Protein, Human (HEK293, His)	P41222 (A23-Q190)	≥95%
HY-P71242A	PTGDS Protein, Human (HEK293, C-His)	P41222 (A23-Q190)	≥95%

Related Diseases

Diseases

Alias

Intracranial Hypotension

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

Cerebrospinal Fluid Leak

Csf Leak	Csf Otorrhea
Csf Rhinorrhea	Spinal Csf Leak
Spinal Cerebrospinal Fluid Leak	Cerebrospinal Fluid Rhinorrhea

Egg Allergy

Allergy To Eggs	Allergies Egg
Egg Hypersensitivity

Macular Holes

Macular Hole

Complete Androgen Insensitivity Syndrome

Cais	Complete Androgen Resistance Syndrome
Androgen Insensitivity Syndrome Complete	Androgen Insensitivity, Complete
Androgen-Insensitivity Syndrome	Testicular Feminization

Idiopathic Hypersomnia

Primary Hypersomnia	Idiopathic Hypersomnolence
Idiopathic Excessive Sleepiness	Hypersomnolence, Idiopathic
Disorder Of Excessive Somnolence	Hypersomnia
Excessive Somnolence

Hypersomnia

Hypersomnia Due To Substances Including Medications

Hypersomnolence Due To Substances Including Medications

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Otorrhea

Discharging Ear

Intracranial Abscess

Abscess Of Brain	Brain Empyema
Cranial Abscess	Intracerebral Abscess
Cerebral Abscess	Cerebral Embolic Abscess
Cerebral Pyogenic Abscess	Septic Brain Infection
Temporosphenoidal Abscess	Ventricular Empyema
Intracranial Suppuration	Intracranial Vein Sinus Abscess

Orbital Cyst

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome	AIS
Testicular Feminization Syndrome	Androgen Receptor Deficiency
Dhtr Deficiency	Dihydrotestosterone Receptor Deficiency
Ar Deficiency	Testicular Feminization
Tfm	Androgen Insensitivity
Androgen-Insensitivity Syndrome	Goldberg-Maxwell Syndrome
Complete Androgen Insensitivity Syndrome	Cais
Feminisation - Testicular	Goldberg - Maxwell Syndrome
Androgen Insensitivity Syndrome, Complete	Morris Syndrome
Ary	AR
Insensitivity Syndrome, Androgen	Androgen Insensitivity Nos

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Beach Ear

Acute Swimmer'S Ear	Acute Bacterial Inflammation Of External Ear
Acute Otitis Externa, Diffuse	Acute Swimmers' Ear
Tank Ear

Disorder Of Sexual Development

Disorder Of Sex Development	Disorders Of Sex Development
Sex Development Disorder	Sex Differentiation Disease
Dsd	Sex Differentiation Disorders

Pulsating Exophthalmos

Diabetes Mellitus

Diabetes

Fabry Disease

Alpha-Galactosidase A Deficiency	Anderson-Fabry Disease
Angiokeratoma Corporis Diffusum	Ceramide Trihexosidase Deficiency
Fabry Disease, Cardiac Variant	Fabry'S Disease
Hereditary Dystopic Lipidosis	Gla Deficiency
FD	Alpha Galactosidase Deficiency
Deficiency Of Melibiase	Angiokeratoma, Diffuse
Angiokeratoma Diffuse	Diffuse Angiokeratoma

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Fibrous Meningioma

Fibroblastic Meningioma

Meningocele

Isolated Spina Bifida	Spina Bifida
Cleft Spine	Open Spine
Rachischisis	Spinal Dysraphism
Spinal Meningocele	Congenital Meningocele

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Communicating Hydrocephalus

Acquired Communicating Hydrocephalus

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11374	PTGDS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTGDS	RGD	RGD:3433
Mus musculus	PTGDS	MGD	MGI:99261
Canis familiaris	PTGDS	VGNC	VGNC:55792
Others	PTGDS	NCBI

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