PTGDS - prostaglandin D2 synthase Gene

Also Known as PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5730

About PTGDS

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:136,977,504-136,981,742 (from NCBI)

This gene has 10 transcripts (splice variants), 161 orthologues and 12 paralogues. Biased expression in testis (RPKM 1025.8), heart (RPKM 481.7) and 13 other tissues.

Summary

The protein encoded by this gene is a glutathione-independent Prostaglandin D Synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]

PTGDS Products (1)

mRNA	Protein	Name
NM_000954.6	NP_000945.3	prostaglandin-H2 D-isomerase precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fatty acid binding	IDA IDA: Inferred from direct assay	20667974	GOA
enables prostaglandin-D synthase activity	IDA IDA: Inferred from direct assay	20347284	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16713569	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	20347284	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	7692978	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	19878301	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	9065498	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGDS Protein Structure

Lipocalin

0
100
190 a.a.

Protein Preferred Names	Protein Names
prostaglandin-H2 D-isomerase	PGD2 synthase

PTGDS Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTGDS	P41222	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	PTGDS	P41222	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	PTGDS	P41222	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	PTGDS	P41222	KRTAP12-3	Homo sapiens	P60328	Validated Y2H	32296183
Intra	PTGDS	P41222	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	PTGDS	P41222	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	PTGDS	P41222	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	PTGDS	P41222	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	PTGDS	P41222	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	PTGDS	P41222	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	PTGDS	P41222	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	PTGDS	P41222	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	PTGDS	P41222	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	PTGDS	P41222	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	PTGDS	P41222	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	PTGDS	P41222	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	PTGDS	P41222	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	PTGDS	P41222	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PTGDS	P41222	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PTGDS	P41222	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTGDS Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71242	PTGDS Protein, Human (HEK293, His, solution)	P41222 (A23-Q190)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P71242A	PTGDS Protein, Human (HEK293, His)	P41222 (A23-Q190)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Intracranial Hypotension
Normal Pressure Hydrocephalus	Low Pressure Hydrocephalus Hydrocephalus Normal Pressure Hydrocephalus, Normal Pressure Normal Pressure Hydrocephalus Nos Nph - [Normal Pressure Hydrocephalus] Normal Pressure Hydrocephaly
Cerebrospinal Fluid Leak	Csf Leak Csf Otorrhea Csf Rhinorrhea Spinal Csf Leak Spinal Cerebrospinal Fluid Leak Cerebrospinal Fluid Rhinorrhea
Egg Allergy	Allergy To Eggs Allergies Egg Egg Hypersensitivity
Macular Holes	Macular Hole
Complete Androgen Insensitivity Syndrome	Cais Complete Androgen Resistance Syndrome Androgen Insensitivity Syndrome Complete Androgen Insensitivity, Complete Androgen-Insensitivity Syndrome Testicular Feminization
Idiopathic Hypersomnia	Primary Hypersomnia Idiopathic Hypersomnolence Idiopathic Excessive Sleepiness Hypersomnolence, Idiopathic Disorder Of Excessive Somnolence Hypersomnia Excessive Somnolence
Hypersomnia	Hypersomnia Due To Substances Including Medications Hypersomnolence Due To Substances Including Medications
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Otorrhea	Discharging Ear
Intracranial Abscess	Abscess Of Brain Brain Empyema Cranial Abscess Intracerebral Abscess Cerebral Abscess Cerebral Embolic Abscess Cerebral Pyogenic Abscess Septic Brain Infection Temporosphenoidal Abscess Ventricular Empyema Intracranial Suppuration Intracranial Vein Sinus Abscess
Orbital Cyst
Androgen Insensitivity Syndrome	Androgen Resistance Syndrome AIS Testicular Feminization Syndrome Androgen Receptor Deficiency Dhtr Deficiency Dihydrotestosterone Receptor Deficiency Ar Deficiency Testicular Feminization Tfm Androgen Insensitivity Androgen-Insensitivity Syndrome Goldberg-Maxwell Syndrome Complete Androgen Insensitivity Syndrome Cais Feminisation - Testicular Goldberg - Maxwell Syndrome Androgen Insensitivity Syndrome, Complete Morris Syndrome Ary AR Insensitivity Syndrome, Androgen Androgen Insensitivity Nos
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Beach Ear	Acute Swimmer'S Ear Acute Bacterial Inflammation Of External Ear Acute Otitis Externa, Diffuse Acute Swimmers' Ear Tank Ear
Disorder Of Sexual Development	Disorder Of Sex Development Disorders Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Sex Differentiation Disorders
Pulsating Exophthalmos
Diabetes Mellitus	Diabetes
Fabry Disease	Alpha-Galactosidase A Deficiency Anderson-Fabry Disease Angiokeratoma Corporis Diffusum Ceramide Trihexosidase Deficiency Fabry Disease, Cardiac Variant Fabry'S Disease Hereditary Dystopic Lipidosis Gla Deficiency FD Alpha Galactosidase Deficiency Deficiency Of Melibiase Angiokeratoma, Diffuse Angiokeratoma Diffuse Diffuse Angiokeratoma
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Fibrous Meningioma	Fibroblastic Meningioma
Meningocele	Isolated Spina Bifida Spina Bifida Cleft Spine Open Spine Rachischisis Spinal Dysraphism Spinal Meningocele Congenital Meningocele
Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive Hydrocephalus, X-Linked Hydrocephalus Adverse Event Hydrocephaly Nos
Communicating Hydrocephalus	Acquired Communicating Hydrocephalus
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11374	PTGDS Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18401	Ptgds Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24882	Ptgds Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PTGDS	RGD	RGD:3433
Mus musculus	PTGDS	MGD	MGI:99261
Canis familiaris	PTGDS	VGNC	VGNC:55792
Others	PTGDS	NCBI