4F-Docetaxel
4F-Docetaxel (4FDT) is a fluorinated docetaxel analog. 4F-Docetaxel has anti-hepatoma activity and can be used for research of hepatocellular carcinoma (HCC).
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- No. CAS: 912272-09-4
- Fòrmula: C43H49F4NO14
- Peso molecular:879.84
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCD-18Co | IC50 |
17.13 μM
Compound: 4FDT
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Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 32203786] |
| HCT-116 | IC50 |
0.1 nM
Compound: 4FDT
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 32203786] |
| HCT-116 | IC50 |
0.1 x 10-3 μM
Compound: 4FDT
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 32203786] |
| HEK293 | IC50 |
0.36 μM
Compound: 4FDT
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay
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[PMID: 32203786] |
| SK-OV-3 | IC50 |
3.4 x 10-2 μM
Compound: 14f
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Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
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[PMID: 18524425] |
| SK-OV-3 | IC50 |
34 nM
Compound: 14f
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Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 72 hrs by SRB assay
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[PMID: 18524425] |
| SW-620 | IC50 |
0.28 μM
Compound: 4FDT
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Cytotoxicity against human SW-620 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human SW-620 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 32203786] |
4F-Docetaxel shows cytotoxic activity against several tumor cell lines, with IC50s of 0.049 μM (95-D), 0.070 μM (SKOV3), 0.958 μM (HCT-116), 0.021 μM (HepG2), 0.022 μM (Bel-7402), 0.014 μM (SMMC-7721), 0.011 μM (SGC-7901), 0.043 μM (MDA-MB-231), 0.017 μM (A2780), 0.012 μM (KB), 0.006 μM (HL-60), 6.6 μM (U2OS), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 912272-09-4
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Peso molecular 879.84
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Fòrmula C43H49F4NO14
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SMILES
CC(O[C@]12[C@@]3([H])[C@@H]([C@]4(C(C)(C([C@H](C([C@@]3([C@H](C[C@@]1([H])OC2)O)C)=O)O)=C([C@H](C4)OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C)(C)C(F)(F)F)=O)=O)C)C)O)OC(C6=CC(F)=CC=C6)=O)=O
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Synonyms
4FDT
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4F-Docetaxel Related Classifications
HY-173387 Related Classifications
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