Antibacterial agent 139
Antibacterial agent 139 has antibacterial activity against Gram-positive bacteria. Antibacterial agent 139 has anti-MRSA, anti-VISA, and anti-LRSE activities. Antibacterial agent 139 depolarizes the bacterial cell membrane.
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- Fòrmula: C28H29ClF3N3O2
- Peso molecular:532.00
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BJ | IC50 |
>25 μg/mL
Compound: 44
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Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 36958177] |
| MRC5 | IC50 |
12.5 μg/mL
Compound: 44
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 36958177] |
Antibacterial agent 139 (Compound 44) (18 h) inhibits the growth of biofilm-forming S. aureus and S. epidermidis strains, with MIC values less than 12.5 μg/mL[1].
Antibacterial agent 139 (24 h) shows citotoxicity against lung and skin fibroblast cell lines (MCR-5 and BJ), with IC50s of 12.5 and >25 μg/mL[1].
Antibacterial agent 139 (60 min) is metabolically stable in rat liver microsomes, displaying a low Clearance value (8.94 μL/min/mg)[1].
Antibacterial agent 139 depolarizes the bacterial cell membrane[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MSSA, MSSE, SP, MRSA, VISA, LRSE
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Concentration:0-12.5 μg/mL
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Incubation Time:18 h
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Result:MIC values : 3.125, 3.125, 6.25, 0.78, 3.125, 3.125 μg/mL respectively.
Chemical Information
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Peso molecular 532.00
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Fòrmula C28H29ClF3N3O2
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SMILES
O=C(NC1CCN(CC1)CCC(C2=CC=CC=C2)OC3=CC=CC(C(F)(F)F)=C3)NC4=CC=CC(Cl)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibacterial agent 139 Related Classifications
HY-149095 Related Classifications
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