Antitubercular agent-57
Antitubercular agent-57 is a selective antimycobacterial agent with low in vitro toxicity against mammalian cell lines including hepatocyte cell lines. Antitubercular agent-57 exhibits activity against drug-sensitive, multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis strains, and shows no cross-resistance with first-line or second-line antitubercular agents. Antitubercular agent-57 has no activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. Antitubercular agent-57 can be used in the research of tuberculosis and multidrug-resistant tuberculosis.
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- No. CAS: 461431-74-3
- Fòrmula: C13H16N4O3
- Peso molecular:276.29
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
Antitubercular agent-57 (compound 10) (0.03-1000 μM; 7-21 d) potently inhibits the growth of drug-susceptible and multidrug-resistant Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium, with a MIC of 0.25 μM against drug-susceptible and multidrug-resistant Mycobacterium tuberculosis[1].
Antitubercular agent-57 (0.488-500 μM; 24-120 h) exhibits no in vitro antifungal activity against the tested yeast and mold strains, with an MIC value >500 μM[1].
Antitubercular agent-57 (0.488-500 μM; 24-48 h) exhibits extremely low in vitro antibacterial activity against the tested Gram-positive and Gram-negative strains, with MIC values ≥250 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HuH7 (human hepatocellular carcinoma), A431 (human epidermoid carcinoma), MDCK (Madin-Darby canine kidney), HepG2 (human hepatocellular carcinoma)
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Concentration:30 μM
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Incubation Time:48 h
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Result:Resulted in relative cell viability of 137% (HuH7) compared to vehicle-treated controls.
Resulted in relative cell viability of 90% (A431) compared to vehicle-treated controls.
Resulted in relative cell viability of 84% (MDCK) compared to vehicle-treated controls).
Resulted in relative cell viability of 145% (HepG2) compared to vehicle-treated controls.
Yielded a selectivity index (SI=IC50(HepG2)/MIC(M.
tuberculosis)) of >120.
Chemical Information
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No. CAS 461431-74-3
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Peso molecular 276.29
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Fòrmula C13H16N4O3
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SMILES
CC(C)(C)C(C=C1)=CC=C1OC2=NC([N+]([O-])=O)=NN2C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitubercular agent-57 Related Classifications
HY-124195 Related Classifications
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