BTA-EG6
BTA-EG6 is a brain-penetrant aggregated amyloid-β (Aβ) peptide binder with a Kd of 290 nM for Aβ1-42. BTA-EG6 binds to aggregated Aβ and forms protein-resistive coatings that block interactions between Aβ and catalase. BTA-EG6 protects neuroblastoma cells from Aβ-induced toxicity and oxidative stress, and inhibits Aβ-induced increases in cellular hydrogen peroxide (H2O2) levels. BTA-EG6 can be used for the research of alzheimer’s disease (AD).
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- No. CAS: 921193-29-5
- Fòrmula: C26H36N2O6S
- Peso molecular:504.64
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
BTA-EG6 (0-500 μM; 24 h) is toxic to differentiated SH-SY5Y human neuroblastoma cells with an IC50 of 69 ± 5 μM after 24 h of treatment[1].
BTA-EG6 (overnight) binds to aggregated amyloid-β 1-42 peptides with a Kd of 290 ± 60 nM following overnight incubation[1].
BTA-EG6 (5-20 μM; 24 h) dose-dependently protects differentiated SH-SY5Y human neuroblastoma cells from 25 μM aggregated amyloid-β 1-42-induced toxicity[1].
BTA-EG6 (1-40 μM; 24 h) dose-dependently reduces 25 μM aggregated amyloid-β 1-42-induced hydrogen peroxide (H2O2) levels in differentiated SH-SY5Y human neuroblastoma cells, normalizing levels at 40 μM after 24 h of treatment[1].
BTA-EG6 (40 μM; 12 h) inhibits the interaction of catalase with immobilized aggregated amyloid-β 1-42 peptides in SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Differentiated SH-SY5Y human neuroblastoma cells exposed to aggregated Aβ 1-42 peptides
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Concentration:5, 10, 20 μM (in presence of 25 μM aggregated Aβ 1-42)
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Incubation Time:24 h
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Result:Increased cell viability in a dose-dependent manner, over 80% at 20 μM, which was statistically significant compared to cells treated with Aβ alone.
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Cell Line:SH-SY5Y cells
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Concentration:40 μM
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Incubation Time:12 h
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Result:Reduced fluorescence intensity of amyloid-β 1-42.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 921193-29-5
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Peso molecular 504.64
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Fòrmula C26H36N2O6S
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SMILES
OCCOCCOCCOCCOCCOCCNC1=CC=C(C2=NC3=C(S2)C=C(C)C=C3)C=C1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BTA-EG6 Related Classifications
HY-182328 Related Classifications
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