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Referencia número: HY-183180

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CGRP antagonist-8

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine.

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No. CAS: 1610413-85-8
Fòrmula: C₄₀H₄₇N₉O₅S
Peso molecular:765.92

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

CGRP antagonist-8 Chemical Structure

No. CAS: 1610413-85-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
SK-N-MC	EC₅₀	100 nM Compound: 8	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	[PMID: 24794104]

In Vitro

CGRP antagonist-8 (Compound 8) potently inhibits CGRP receptor binding in SK-N-MC cell membrane tissue with an IC₅₀ of 2.7 nM^[1].
CGRP antagonist-8 acts as a CGRP receptor antagonist in SK-N-MC cells, with an EC₅₀ of 100 nM in the cAMP functional assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 1610413-85-8
Peso molecular 765.92
Fòrmula C₄₀H₄₇N₉O₅S
SMILES

O=C1N(C2CCN(CC2)C(N[C@@H](C(N[C@@H](CCCCN)C(N3CCN(C4=CC=NC=C4)CC3)=O)=O)CC5=CC6=CC=CC=C6S5)=O)C(NC7=CC=CC=C71)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Dasgupta B, et al. Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist. Bioorg Med Chem Lett. 2014;24(12):2744-2748. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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