CP-467688
CP-467688 is an orally active retinotoxic agent. CP-467688 induces increased lysosome volume, phagocytosis inhibition and autophagy inhibition in retinal cells. CP-467688 is applicable to the research of retinopathy.
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- No. CAS: 909576-25-6
- Fòrmula: C27H27ClF3N3O3
- Peso molecular:533.97
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
CP-467688 (1.2-100.0 mM; 24 h) induces concentration-dependent lysosomal volume expansion in ARPE-19 cells[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits the phagocytic function of ARPE-19 cells[1].
CP-467688 (1.2-100.0 mM; 24 h) inhibits autophagic flux in ARPE-19 cells, with the peak punctate LC3 fluorescence intensity being approximately 5 times that of the control group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:ARPE-19
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Concentration:1.5, 1.2, 3.1, 3.7, 11.1, 33.3, 100.0 mM
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Incubation Time:24 h
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Result:Induced a concentration-dependent increase in punctate LC3 fluorescence intensity relative to vehicle control, with peak activity reaching approximately 5-fold greater than control.
Triggered a > 2-fold increase in LC3 intensity at multiple tested concentrations.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (male)[1]
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Dosage:100 mg/kg; 500 mg/kg
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Administration:p.o.; daily; 7-14 days
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Result:Induced retinal lesions characterized by disrupted retinal pigmented epithelium (RPE) with multiple, round-to-oval vacuoles of variable size in RPE cytoplasm.
Chemical Information
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No. CAS 909576-25-6
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Peso molecular 533.97
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Fòrmula C27H27ClF3N3O3
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SMILES
O=C(OC)NCCN1CC2=C(C=C(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)C=C2)CC1.Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CP-467688 Related Classifications
HY-111159 Related Classifications
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