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Referencia número: HY-132913

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Cyclopropenone probe 1

Cyclopropenone probe 1 can specifically and efficiently modify a triple-negative breast cancer driver, glutathione S-transferase pi-1 (GSTP1), by covalently binding at the catalytic active site. Cyclopropenone probe 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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No. CAS: 2771119-22-1
Fòrmula: C₁₂H₈O₂
Peso molecular:184.19

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Cyclopropenone probe 1 Chemical Structure

No. CAS: 2771119-22-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
Bcap37	IC₅₀	45 μM Compound: CY-1	Antiproliferative activity against human BcaP37 cells assessed as cell viability incubated for 24 hrs by CCk8 assay Antiproliferative activity against human BcaP37 cells assessed as cell viability incubated for 24 hrs by CCk8 assay	[PMID: 34623802]
MDA-MB-231	IC₅₀	0.78 μM Compound: CY1	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 36762554]

Chemical Information

No. CAS 2771119-22-1
Peso molecular 184.19
Fòrmula C₁₂H₈O₂
SMILES

C#CCOC1=CC=C(C=C1)C2=CC2=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Fan Y, et al. Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery". J Med Chem. 2021 Nov 11;64(21):15582-15592. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cyclopropenone probe 1

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Cyclopropenone probe 1

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Cyclopropenone probe 1 Related Classifications

HY-132913 Related Classifications