DOTA-cTMTP1
DOTA-cTMTP1 is a cyclic tumor-homing peptide precursor molecule. DOTA-cTMTP1 selectively binds to XPNPEP2 on highly metastatic tumor cells, accumulates and retains in hepatocellular carcinoma tumors, and maintains a high tumor-to-liver contrast over time in small animal models. After radiolabeling with 68Ga, DOTA-cTMTP1 forms a PET probe for positron emission tomography (PET) imaging of hepatocellular carcinoma (HCC).
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- Fòrmula: C55H92N20O21S2
- Peso molecular:1433.57
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
DOTA-cTMTP1 (20 μg; 10 min) exhibits > 99% radiolabeling efficiency when incubated with [68Ga]GaCl3 at 95 °C for 10 min, producing [68Ga]Ga-DOTA-cTMTP1 with a specific activity of 5.19 MBq/nmol[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
[68Ga]Ga-DOTA-cTMTP1 (i.v.; single dose) enables clear visualization of small HCC lesions in a transgenic mouse model, with increasing tumor-to-liver ratios over 120 min postinjection[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c nude (male, 5-6 weeks old, ~20 g)[1]
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Dosage:5.2 MBq
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Administration:i.v.; single dose
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Result:Reached tumor uptake of 1.3 %ID/g at 15 min, 1.09 %ID/g at 30 min, and 0.74 %ID/g at 150 min postinjection.
Showed tumor uptake of 0.98 %ID/g at 30 min with retention at later time points.
Achieved tumor-to-liver ratios of 2.65 at 30 min, 2.37 at 60 min, 2.14 at 120 min, and 2.69 at 150 min.
Reached tumor-to-muscle ratio of 11.17 at 150 min.
Reduced tumor uptake to 0.36 %ID/g at 30 min and 0.32 %ID/g at 60 min after coinjection of unlabeled TMTP1.
Decreased blood radioactivity from 1.11 %ID/g at 30 min to 0.48 %ID/g at 60 min, and then to 0.22 %ID/g at 120 min.
Chemical Information
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Peso molecular 1433.57
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Fòrmula C55H92N20O21S2
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Sequence
DOTA-Gly-Gly-Gly-Cys-Gly-Asn-Val-Val-Arg-Gln-Gly-Cys (Disulfide bridge: Cys1-Cys9)
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Sequence Shortening
DOTA-GGG-CGNVVRQGC (Disulfide bridge: Cys1-Cys9)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DOTA-cTMTP1 Related Classifications
HY-P11816 Related Classifications
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