Fentiazac
Based on 1 publication(s) in Google Scholar
Fentiazac, alkanoic acid derivative, is an orally active non-steroidal anti-inflammatory agent, with analgesic, antipyretic and platelet anti-aggregation activity. Fentiazac can be used to research inflammatory diseases such as rheumatoid arthritis, osteoarthritis and tendinitis.
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- Pureza: 99.81%
- No. CAS: 18046-21-4
- Fòrmula: C17H12ClNO2S
- Peso molecular:329.81
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Immunology/Inflammation Compound Library
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Publications Citing Use of MedChemExpress (MCE) Fentiazac
More
Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
0.55 μM
Compound: 5j
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Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells
Displacement of[3H]PGD2 from human CRTH2 receptor expressed in african green monkey COS7 cells
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[PMID: 20031403] |
Tolerance of Fentiazac in rat, monkey and dog[1].
| Species | Tolerant dosage | Tolerant administration day |
| Rat | 0-50 mg/kg/day | 90 days |
| Red pated monkey | 40 mg/kg/day | 90 days |
| 0-30 mg/kg/day | 180 days | |
| African green monkey | 0-8 mg/kg/day | 79 to 93 days |
| dog | 16.6 mg/kg/day | 180 days |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 18046-21-4
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Appearance Solid
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Peso molecular 329.81
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Fòrmula C17H12ClNO2S
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Color White to off-white
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SMILES
O=C(CC1=C(N=C(S1)C2=CC=CC=C2)C3=CC=C(C=C3)Cl)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
2026 Mar 20;17(1):2285. PMID: 41862483
Solvente y solubilidad
DMSO : 100 mg/mL (303.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.58 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.58 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0321 mL | 15.1603 mL | 30.3207 mL | 75.8017 mL |
| 5 mM | 0.6064 mL | 3.0321 mL | 6.0641 mL | 15.1603 mL | |
| 10 mM | 0.3032 mL | 1.5160 mL | 3.0321 mL | 7.5802 mL | |
| 15 mM | 0.2021 mL | 1.0107 mL | 2.0214 mL | 5.0534 mL | |
| 20 mM | 0.1516 mL | 0.7580 mL | 1.5160 mL | 3.7901 mL | |
| 25 mM | 0.1213 mL | 0.6064 mL | 1.2128 mL | 3.0321 mL | |
| 30 mM | 0.1011 mL | 0.5053 mL | 1.0107 mL | 2.5267 mL | |
| 40 mM | 0.0758 mL | 0.3790 mL | 0.7580 mL | 1.8950 mL | |
| 50 mM | 0.0606 mL | 0.3032 mL | 0.6064 mL | 1.5160 mL | |
| 60 mM | 0.0505 mL | 0.2527 mL | 0.5053 mL | 1.2634 mL | |
| 80 mM | 0.0379 mL | 0.1895 mL | 0.3790 mL | 0.9475 mL | |
| 100 mM | 0.0303 mL | 0.1516 mL | 0.3032 mL | 0.7580 mL |
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