Ctsl - cathepsin L Gene

Also Known as CatL; CATHL; Ctsl1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25697

About Ctsl

Primary_assembly 17: 764,309-770,548 forward strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 711 orthologues, 27 paralogues and is associated with 26 phenotypes. Biased expression in Kidney (RPKM 13282.8), Liver (RPKM 4121.4) and 6 other tissues.

Summary

Enables kininogen binding activity; peptidase activity; and peptide binding activity. Involved in several processes, including autophagic cell death; reproductive structure development; and response to odorant. Located in several cellular components, including external side of plasma membrane; microvillus; and perikaryon. Colocalizes with apical part of cell and secretory granule. Used to study hepatocellular carcinoma. Biomarker of several diseases, including brain ischemia; hyperthyroidism; muscular atrophy; otitis media; and pancreatitis. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSV (Cathepsin V). [provided by Alliance of Genome Resources, Apr 2022]

Ctsl Products (1)

mRNA Protein Name
NM_013156.2 NP_037288.1 procathepsin L preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
8702598 RGD
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
12788072 RGD
enables kininogen binding IPI
IPI: Inferred from physical interaction
3356189 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
8702598 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
2470410 RGD
Biological Process GO Annotation Evidence Referencias Source
involved in Sertoli cell differentiation IEP
IEP: Inferred from expression pattern
15647457 RGD
involved in autophagic cell death IEP
IEP: Inferred from expression pattern
16176344 RGD
involved in cellular response to starvation IEP
IEP: Inferred from expression pattern
16176344 RGD
involved in decidualization IEP
IEP: Inferred from expression pattern
15644143 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
16135663 RGD
involved in nerve development IEP
IEP: Inferred from expression pattern
15686940 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
11788364 RGD
involved in proteolysis IDA
IDA: Inferred from direct assay
12788072 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
15705658 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
9877467 RGD
involved in response to gonadotropin IEP
IEP: Inferred from expression pattern
14563703 RGD
involved in response to odorant IEP
IEP: Inferred from expression pattern
23103411 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18465118 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
9876020 RGD
Cellular Component GO Annotation Evidence Referencias Source
located in apical part of cell IDA
IDA: Inferred from direct assay
15761664 RGD
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
19284293 RGD
located in microvillus IDA
IDA: Inferred from direct assay
15085256 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16176344 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
18410501 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsl Protein Structure

Inhibitor_I29

Inhibitor_I29: smart00848 (28 - 86)

Peptidase_C1

Peptidase_C1: pfam00112 (113 - 331)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

procathepsin L

  • CP-2

  • MEP

  • cathepsin L1

  • cyclic protein 2

  • major excreted protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-128140 Z-FY-CHO Inhibitor 96.18% Unkown
HY-119293 K777 Inhibitor 99.14% Unkown
HY-170772 Dual Cathepsin L/JAK-IN-1 Inhibitor 98.47% Unkown
HY-RS03340 CTSL Human Pre-designed siRNA Set A / Unkown
HY-119293A K777 tosylate Inhibitor / Unkown
HY-157477 SARS-CoV-2 3CLpro-IN-22 Inhibitor / Unkown
HY-158022 CTSL/CAPN1-IN-1 Inhibitor / Unkown
HY-161342 CTSL/CAPN1-IN-2 Inhibitor / Unkown
HY-181676 Anti-inflammatory agent 113 Inhibitor / Unkown
HY-RS03341 Ctsl Mouse Pre-designed siRNA Set A / Unkown
HY-RS03342 Ctsl Rat Pre-designed siRNA Set A / Unkown
HY-163029 CTSL/B-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsl NCBI NCBI:1514