CTSL - cathepsin L Gene

Also Known as MEP; CATL; CTSL1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1514

About CTSL

Cytogenetic location: 9q21.33 Genomic coordinates (GRCh38): 9:87,726,119-87,731,469 (from NCBI)

This gene has 43 transcripts (splice variants), 708 orthologues and 12 paralogues. Broad expression in placenta (RPKM 162.6), kidney (RPKM 60.4) and 23 other tissues.

Summary

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include Collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil Elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]

CTSL Products (10)

mRNA	Protein	Name
NM_001257971.2	NP_001244900.1	procathepsin L isoform 1 preproprotein
NM_001382767.1	NP_001369696.1	procathepsin L isoform 4 precursor
NM_001257972.2	NP_001244901.1	procathepsin L isoform 1 preproprotein
NM_001912.5	NP_001903.1	procathepsin L isoform 1 preproprotein
NM_001382768.1	NP_001369697.1	procathepsin L isoform 4 precursor
NM_001382766.1	NP_001369695.1	procathepsin L isoform 4 precursor
NM_001382758.1	NP_001369687.1	procathepsin L isoform 3
NM_145918.3	NP_666023.1	procathepsin L isoform 1 preproprotein
NM_001382757.1	NP_001369686.1	procathepsin L isoform 1 preproprotein
NM_001257973.2	NP_001244902.1	procathepsin L isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IDA IDA: Inferred from direct assay	22952693	GOA
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	12809493	GOA
enables cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	28743268	GOA
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	8811434	GOA
enables fibronectin binding	IPI IPI: Inferred from physical interaction	22952693	GOA
enables histone binding	IDA IDA: Inferred from direct assay	21326229	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12504904	GOA
enables proteoglycan binding	IPI IPI: Inferred from physical interaction	22952693	GOA
enables serpin family protein binding	IPI IPI: Inferred from physical interaction	21383048	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adaptive immune response	IEP IEP: Inferred from expression pattern	15196205	GOA
involved in cellular response to thyroid hormone stimulus	IEP IEP: Inferred from expression pattern	21217776	GOA
involved in collagen catabolic process	IDA IDA: Inferred from direct assay	10716919	GOA
involved in fusion of virus membrane with host endosome membrane	IDA IDA: Inferred from direct assay	16081529	GOA
involved in fusion of virus membrane with host plasma membrane	IDA IDA: Inferred from direct assay	32855215	GOA
involved in protein autoprocessing	IDA IDA: Inferred from direct assay	9468501	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	8811434	GOA
involved in proteolysis involved in protein catabolic process	IDA IDA: Inferred from direct assay	22952693	GOA
involved in receptor-mediated endocytosis of virus by host cell	IDA IDA: Inferred from direct assay	16081529	GOA
involved in symbiont entry into host cell	IDA IDA: Inferred from direct assay	16339146	GOA
involved in zymogen activation	IDA IDA: Inferred from direct assay	9468501	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	22952693	GOA
located in lysosome	IDA IDA: Inferred from direct assay	1837142	GOA
located in multivesicular body	IDA IDA: Inferred from direct assay	22365146	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22365146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTSL Protein Structure

Inhibitor_I29

Peptidase_C1

0
100
200
300
333 a.a.

Protein Preferred Names	Protein Names
procathepsin L	cathepsin L1 major excreted protein

CTSL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	CTSL	P07711	srp-6	Caenorhabditis elegans	G5EFH4	Enzymatic Study	17889653
Cross	CTSL	P07711	S	SARS-CoV-2	P0DTC2	Protease Assay	33774649
Intra	CTSL	P07711	SGTA	Homo sapiens	O43765	Y2H Array	25416956
Intra	CTSL	P07711	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CTSL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7754	Cathepsin L1 Protein, Human (HEK293, His, solution)	P07711-1 (T18-V333)	≥ 95%, as determined by reducing SDS-PAGE.

CTSL Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82802	Cathepsin L/V/K/H Antibody (YA2547)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P86837	Cathepsin L/V/K/H Antibody (YA6530)	IHC-P, IHC-F, IF-Tissue	Human, Mouse
HY-P86838	Cathepsin L Antibody (YA6531)	WB, IHC-P, FC	Human, Mouse, Rat, Monkey

Related Diseases

Diseases	Alias
Taeniasis	Beef Tapeworm Infection Infection By Taeniarhynchus Saginatus Taenia Saginata Infectious Disease Taenia Saginata Infection Pork Tapeworm Infection Armed Tapeworm Infection Infection By Taenia Solium Intestinal Taenia Solium Infection Pork Tapeworm Taenia Solium Taeniasis Adult Pork Tapeworm Infection Adult Pork Tapeworm Beef Tapeworm Infection By Taenia Saginata Unarmed Tapeworm Infection Taenia Saginata Taeniasis Infection Due To Adult Tapeworm Taenia Saginata Mediocanellata Taenia Infection Infestation By Taenia Saginata Infestation By Taenia Mediocanellata
Monieziasis
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Ischemia	Acute Coronary Syndrome
Aortic Aneurysm, Familial Abdominal, 1	Abdominal Aortic Aneurysm Aortic Aneurysm, Familial Abdominal 1 Aneurysm, Abdominal Aortic AAA Aortic Aneurysm, Abdominal AAA1 Aortic Aneurysm, Familial Abdominal Aortic Aneurysm Abdominal Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture Abdomen Aneurysm Abdominal Aorta Aneurysm Aneurysm Of Abdominal Aorta Aortic Abdomen Aneurysm Aaa - [Abdominal Aortic Aneurysm] Abdominal Aneurysm Abdominal Aorta Aneurysm Rupture Abdominal Aorta Aneurysm Ruptured Abdominal Aortic Aneurysm Which Has Ruptured Ruptured Aaa Abdomen Aorta Aneurysm Ruptured Abdomen Aorta Rupture Abdomen Aortic Aneurysm Rupture Abdomen Aneurysm Rupture Abdomen Aortic Aneurysm Ruptured Abdomen Aortic Rupture Abdominal Aorta Rupture Abdominal Aortic Rupture Rupture Abdomen Aorta Aneurysm Rupture Abdominal Aortic Aneurysm Ruptured Abdomen Aneurysm Ruptured Abdomen Aorta Ruptured Abdomen Aortic Ruptured Abdominal Aneurysm Ruptured Abdominal Aorta Ruptured Abdominal Aortic Ruptured Aorta Abdominalis Aneurysm False Abdomen Aorta Aneurysm Ruptured False Abdominal Aortic Aneurysm Ruptured False Abdominal Aorta Aneurysm Ruptured False Abdomen Aortic Aneurysm Ruptured
Tick Infestation	Tick Infestations
Fascioliasis	Fasciola Hepatica Infection Infection By Fasciola Sheep Liver Fluke Infection Liver Flukes Fasciola Infestation Sheep Liver Fluke Disease Liver Fluke Infestation Liver Flukes Nos Liver Fluke Infection Liver Fluke Disease
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Toxocariasis	Toxocara Infection Visceral Larva Migrans Larva Migrans, Visceral Infection By Toxascaris Larva Migrans Visceral Larva Migrans Visceralis Toxocaral Visceral Larva Migrans Visceral Larva Migrans Syndrome Toxocara Infestation
Heterophyiasis	Heterophyes Infectious Disease
Trichomoniasis	Trichomonas Infection Trichomonas Infections Disease Due To Trichomonadidae Infection By Trichomonas Trichomonadosis Trichomonas Pruritus Trichomonosis Tricomoniasis
Gingival Overgrowth	Gingival Enlargement Gingival Hyperplasia Gingival Bulge Gingival Enlargement Nos Gingival Hypertrophy Gum Hypertrophy Hyperplasia Gum Gingival Thickening Hyperplasia Of Gingiva Hypertrophy Of Gingiva Hypertrophy Of Mucous Membrane Of Gums
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Parasitic Helminthiasis Infectious Disease	Helminthiasis Intestinal Helminthiasis Helminth Infection Helminthosis Worm Infection Worm Infections Helminth Infections Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata Parasitic Enteritis Metazoal Dysentery Intestinal Worms Nos
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ehf Ebola Fever Ebola Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Papillon-Lefevre Syndrome	Papillon-Lefevre Disease Papillon-Lefèvre Syndrome PLS Keratosis Palmoplantaris With Periodontopathia PALS Papillon Lefevre Syndrome Keratosis Palmoplantar-Periodontopathy Syndrome Papillon-Lefvre Syndrome Hyperkeratosis Palmoplantaris With Periodontosis Keratoris Palmoplantaris With Periodontopathia Keratosis Palmoplantar - Periodontopathy Palmar-Plantar Hyperkeratosis And Concomitant Periodontal Destruction Palmoplantar Keratoderma With Periodontosis Palsy
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Covid-19	2019 Novel Coronavirus 2019-Ncov Infection Covid19 Sars-Cov-2 Infection Wuhan Coronavirus Infection Wuhan Seafood Market Pneumonia Virus Infection
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Sparganosis	Infection By Sparganum Larval Diphyllobothriasis Spirometrosis Infection By Spirometra Larvae Larval Dibothriocephaliasis Sparganosis - Larval Diphyllobothriasis Spirometriosis Larval Dibothriocephalus Infestation Larval Diphyllobothrium Infestation Larval Dibothriocephalus Infection Due To Sparganum Larval Fish Tapeworm Infection Spirometra Larvae Infestation Sparganum Infestation Larval Bothriocephalus Infestation
Metagonimiasis	Trematode Infections Infection By Metagonimus Yokogawai Metagonimus Yokogawai Infection
Severe Acute Respiratory Syndrome	Sars Sars-Cov Infection Sars-1 Sar Deficiency Sars - [Severe Acute Respiratory Syndrome]
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Amebiasis	Amoebiasis Entamoebiasis Chronic Intestinal Amebiasis Amoebiasis, Unspecified Amebic Colitis Amoebic Enteritis Infection Due To Entamoeba Histolytica Amoebic Infection Disease Due To Endamoebidae Amoebiasis Nos
Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant	Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans KFSD
Parasitic Protozoa Infectious Disease	Protozoan Infections Mastigophora Infectious Disease Sarcomastigophora Infectious Disease
Coronavirus Infectious Disease
Dicrocoeliasis	Disease Due To Dicrocoeliidae Lancet Fluke Infection Dicroceliosis Lancet Fluke Disease Lancet Fluke Infestation
Leukodystrophy	Leukodystrophies
Unverricht-Lundborg Syndrome	Unverricht-Lundborg Disease Epm1 Myoclonic Epilepsy Of Unverricht And Lundborg Myoclonus Progressive Epilepsy Of Unverricht And Lundborg Unverricht - Lundborg Disease Unverricht'S Disease Epilepsy, Progressive Myoclonic Type 1 Epilepsy, Progressive Myoclonus 1 Progressive Myoclonus Epilepsy Baltic Myoclonic Epilepsy Baltic Myoclonic Epilepsy Baltic Myoclonus Baltic Myoclonus Epilepsy Lundborg-Unverricht Syndrome Mediterranean Myoclonic Epilepsy Pme Progressive Myoclonic Epilepsy Progressive Myoclonus Epilepsy 1 Uld Myoclonic Epilepsies, Progressive
Benign Meningioma	Meningioma, Benign
Progressive Myoclonus Epilepsy	Pme Progressive Myoclonic Epilepsy Myoclonic Epilepsies, Progressive Unverricht-Lundborg Syndrome
Paragonimiasis	Infection By Paragonimus Lung Fluke Disease Lung Fluke Infection Pulmonary Paragonimiasis Paragonimus Westermani Infection Pulmonary Distomiasis Parasitic Haemoptysis Oriental Lung Fluke Disease Endemic Haemoptysis Paragonimosis Pulmonary Distomatosis Lung Fluke Disorder Infestation By Paragonimus Infection Due To Paragonimus Species Infestation Due To Paragonimus Species Oriental Lung Fluke Infestation Endemic Oriental Haemoptysis
Pycnodysostosis	Pyknodysostosis PKND Pycd Toulouse-Lautrec Syndrome
Marburg Hemorrhagic Fever	Marburg Virus Disease Marburg Disease Green Monkey Disease Mhf Vervet Monkey Disease Mard - [Marburg Disease] Mvd - [Marburg Virus Disease] Marburg Haemorrhagic Fever Mhf - [Marburg Haemorrhagic Fever]
Trypanosomiasis
Cysticercosis	Neurocysticercosis Submacular Cysticercosis Intestinal Taenia Solium Infection Pork Tapeworm Infection Tapeworm Infection: Intestinal Taenia Solum Tapeworm Infection: Pork Tenia Solium Infectious Disease Taeniasis Tenia Solium Infection Cysticerciasis Infection Due To Larval Form Of Taenia Solium
Parasitic Ectoparasitic Infectious Disease	Ectoparasitic Infestations Ectoparasitism
Mandibular Cancer	Mandibular Neoplasms Malignant Neoplasm Of Inferior Maxilla Malignant Neoplasm Of Lower Jaw Bone Malignant Neoplasm Of Mandible Mandible Cancer Mandibular Neoplasm Neoplasm Of Mandible
Clonorchiasis	Oriental Liver Fluke Disease Clonorchis Liver Infection Clonorchiosis Chinese Liver Fluke Disease Hepatic Distomiasis Due To Clonorchis Sinensis Infection Due To Clonorchis Sinensis Hepatic Distomiasis Hepatic Distomatosis Chinese Liver Fluke Disorder Oriental Liver Fluke Disorder Clonorchis Infestation Chinese Liver Fluke Infestation Liver Fluke Disease Due To Clonorchis Sinensis Oriental Liver Fluke Infestation
Metachromatic Leukodystrophy	Arylsulfatase A Deficiency MLD Arsa Deficiency Sulfatide Lipidosis Metachromatic Leukoencephalopathy Cerebral Sclerosis, Diffuse, Metachromatic Form Cerebroside Sulfatase Deficiency Leukodystrophy, Metachromatic Pseudoarylsulfatase A Deficiency Leukodystrophy Metachromatic Sulfatidosis Metachromatic Leukodystrophy, Late Infantile Metachromatic Leukodystrophy Variant Deficiency Of Cerebroside-Sulfatase Scholz Cerebral Sclerosis Sulfatide Lipoidosis Cerebral Sclerosis Diffuse Metachromatic Form Arylsulfatase A Deficiency Disease Cerebroside Sulphatase Deficiency Disease Greenfield Disease Metachromatic Leukodystrophy, Adult Metachromatic Leukodystrophy, Juvenile Leukodystrophy Metachromatic Adult Leukodystrophy Metachromatic Juvenile Leukodystrophy Metachromatic Late Infantile Metachromatic Leukodystrophy, Adult Type Metachromatic Leukodystrophy, Juvenile Type Metachromatic Leukodystrophy, Infant Greenfield'S Disease
Primary Amebic Meningoencephalitis	Pam Naegleria Fowleri Infection Meningoencephalitis Caused By Naegleria Fowleri Primary Amoebic Meningoencephalitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128140	Z-FY-CHO	Inhibitor	96.18%	Unkown
HY-119293	K777	Inhibitor	99.14%	Unkown
HY-170772	Dual Cathepsin L/JAK-IN-1	Inhibitor	98.47%	Unkown
HY-RS03340	CTSL Human Pre-designed siRNA Set A		/	Unkown
HY-119293A	K777 tosylate	Inhibitor	/	Unkown
HY-157477	SARS-CoV-2 3CLpro-IN-22	Inhibitor	/	Unkown
HY-158022	CTSL/CAPN1-IN-1	Inhibitor	/	Unkown
HY-161342	CTSL/CAPN1-IN-2	Inhibitor	/	Unkown
HY-181676	Anti-inflammatory agent 113	Inhibitor	/	Unkown
HY-RS03341	Ctsl Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS03342	Ctsl Rat Pre-designed siRNA Set A		/	Unkown
HY-163029	CTSL/B-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CTSL	VGNC	VGNC:71560
Mus musculus	CTSL	MGD	MGI:88564
Rattus norvegicus	CTSL	RGD	RGD:2448
Others	CTSL	NCBI