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MXD3 - MAX dimerization protein 3 Gene

Also Known as MYX; MAD3; BHLHC13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83463

About MXD3

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,305,499-177,312,752 (from NCBI)

This gene has 9 transcripts (splice variants), 173 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 15.2), colon (RPKM 14.3) and 25 other tissues.

Summary

This gene encodes a member of the Myc superfamily of basic helix-loop-helix leucine zipper transcriptional regulators. The encoded protein forms a heterodimer with the cofactor MAX which binds specific E-box DNA motifs in the promoters of target genes and regulates their transcription. Disruption of the MAX-MXD3 complex is associated with uncontrolled cell proliferation and tumorigenesis. Transcript variants of this gene encoding different isoforms have been described.[provided by RefSeq, Dec 2008]

MXD3 Products (4)

mRNA	Protein	Name
NM_001142935.2	NP_001136407.1	max dimerization protein 3 isoform b
NM_001394986.1	NP_001381915.1	max dimerization protein 3 isoform a
NM_001394987.1	NP_001381916.1	max dimerization protein 3 isoform c
NM_031300.4	NP_112590.1	max dimerization protein 3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Referencias	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MXD3 Protein Structure

HLH

0
100
206 a.a.

Protein Preferred Names	Protein Names
max dimerization protein 3	Max-associated protein 3

MXD3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	MXD3	Q9BW11	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	MXD3	Q9BW11	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	MXD3	Q9BW11	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	MXD3	Q9BW11	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	MXD3	Q9BW11	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	MXD3	Q9BW11	TFIP11	Homo sapiens	Q9UBB9	Anti Tag CoIP	33961781
Intra	MXD3	Q9BW11	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	MXD3	Q9BW11	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	MXD3	Q9BW11	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	MXD3	Q9BW11	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	MXD3	Q9BW11	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	MXD3	Q9BW11	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	MXD3	Q9BW11	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	MXD3	Q9BW11	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	MXD3	Q9BW11	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	MXD3	Q9BW11	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	MXD3	Q9BW11	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	MXD3	Q9BW11	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	MXD3	Q9BW11	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	MXD3	Q9BW11	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956
Intra	MXD3	Q9BW11	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	MXD3	Q9BW11	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	MXD3	Q9BW11	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956
Intra	MXD3	Q9BW11	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	MXD3	Q9BW11	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MXD3 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P82484	Max Dimerization Protein 3 Antibody (YA2229)	WB, IHC-P, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Atrichia With Papular Lesions	Papular Atrichia APL Congenital Atrichia
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS08862	MXD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MXD3	VGNC	VGNC:55224
Macaca mulatta	MXD3	VGNC	VGNC:84451
Canis familiaris	MXD3	VGNC	VGNC:51904
Mus musculus	MXD3	MGD	MGI:104987
Rattus norvegicus	MXD3	RGD	RGD:628624
Others	MXD3	NCBI