Lei-Dab7
Lei-Dab7 is a potent and selective SK2 (KCa2.2) channels blocker with a Kd of 3.8 nM. Lei-Dab7 shows low or no activity on KCa1, KCa3, Kv and Kir2.1 channels.
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- No. CAS: 1061556-49-7
- Fòrmula: C141H236N46O39S6
- Peso molecular:3392.06
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
- Pureza y Documentación
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Help & FAQs
Actividad biológica
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1061556-49-7
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Peso molecular 3392.06
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Fòrmula C141H236N46O39S6
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Sequence
Ala-Phe-Cys-Asn-Leu-Arg-{Dab}-Cys-Gln-Leu-Ser-Cys-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys-Ile-Gly-Asp-Lys-Cys-Glu-Cys-Val-Lys-His-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)
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Sequence Shortening
AFCNLR-{Dab}-CQLSCRSLGLLGKCIGDKCECVKH-NH2 (Disulfide bridge:Cys3-Cys21;Cys8-Cys26;Cys12-Cys28)
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. V G Shakkottai, et al. Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J Biol Chem. 2001 Nov 16;276(46):43145-51. [Content Brief]
[2]. Sabrine Aidi-Knani, et al. Correspondences between the binding characteristics of a non-natural peptide, Lei-Dab7, and the distribution of SK subunits in the rat central nervous system. Eur J Pharmacol. 2015 Apr 5;752:106-11. [Content Brief]
[3]. Bedel Mpari, et al. Small-conductance Ca(2+)-activated K(+) channels: Heterogeneous affinity in rat brain structures and cognitive modulation by specific blockers. Eur J Pharmacol. 2008 Jul 28;589(1-3):140-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lei-Dab7 Related Classifications
HY-P1424 Related Classifications
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