Lomtegovimab
Based on 1 Customer Validation
Lomtegovimab (BI 767551) is a human anti-SARS-COV-2 spike glycoprotein monoclonal antibody. Lomtegovimab binds and neutralizes SARS-CoV-2. Lomtegovimab shows antiviral efficacy. Lomtegovimab has the potential for the research of COVID-19.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.94%
- No. CAS: 2550869-33-3
- Peso molecular:145.58 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Human IgG1 kappa
Virus
Severe acute respiratory syndrome coronavirus 2
Lomtegovimab targets the RBD of SARS-CoV-2 S with a KD value of 1.09 nM[2].
Lomtegovimab shows neutralizing activity with IC50s of 0.001, 0.001, 0.010 µg/mL for SARS-CoV-2 S D614G, SARS-CoV-2 S B.1.1.7, SARS-CoV-2 BavPat1 (B.1), respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice (Ad_ACE2-mCherry)[2]
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Dosage:40 mg/kg
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Administration:I.p. or I.n.; once; three days before infection
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Result:Led to a complete neutralization of infectious SARS-CoV-2 and slightly reduced amounts of viral RNA in the lungs of treated animals.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
4.37406e+007 [NCBI]
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized SARS-CoV-2 S Protein RBD (Omicron, B.1.1.529, HEK293, His, HY-P74447) can bind Lomtegovimab. The EC50 for this effect is 900.9 ng/mL.
Chemical Information
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No. CAS 2550869-33-3
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Appearance Liquid
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Peso molecular 145.58 kDa
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Color Colorless to light yellow
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SMILES
[Lomtegovimab]
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Synonyms
BI 767551; DZIF-10c
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (259 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lomtegovimab Related Classifications
HY-P99710 Related Classifications
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