Magnesium malate
Magnesium malate is an orally active organic acid-chelated magnesium complex. Magnesium malate promotes the release of prostaglandin E2 (PGE2) from macrophages, synergistically stimulates the synthesis/release of calcitonin gene-related peptide (CGRP) from dorsal root ganglion neurons, and upregulates the osteogenic transcription factor RUNX2 in osteoblasts via the Mg2+-PGE2-CGRP axis, thereby promoting osteoblast proliferation. Magnesium malate can be incorporated into calcium phosphate bone cement as a modifying component to improve compressive strength, shorten setting time and enhance disintegration resistance. Magnesium malate increases serum magnesium levels. Magnesium malate can be used in studies related to bone defects and magnesium deficiency.
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- No. CAS: 869-06-7
- Fòrmula: C4H6MgO5
- Peso molecular:158.38
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Actividad biológica
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RUNX2 |
Magnesium malate (5 wt%) incorporated into calcium phosphate bone cement can shorten the final setting time to less than 40 minutes, improve disintegration resistance, and increase compressive strength to 6.18 MPa. It gradually degrades in vitro, continuously releasing magnesium ions, reaching 318.49 mg/L at 35 days[1].
Magnesium malate (5 wt%)-modified calcium phosphate bone cement extracts are biocompatible with MC3T3-E1 pre-osteoblasts, supporting cell adhesion, viability, and proliferation that is significantly greater than control medium after 3 days of culture[1].
Magnesium malate can prolong axonal growth in primary dorsal root ganglion (DRG) neurons and synergistically increase intracellular and secretory CGRP levels in neurons with PGE2; it can upregulate RUNX2 expression in MC3T3-E1 osteoblast progenitor cells, expand ALP-positive areas, and increase calcium nodule formation[1].
Magnesium malate, either as a standalone extract or incorporated into calcium phosphate bone cement, significantly enhances PGE2 release from LPS-induced RAW264.7 macrophages compared to control, CPC, and MgCl2 groups[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Magnesium malate (45-405 mg/70 kg elemental magnesium; p.o.; single dose or two doses 12 hours apart) significantly increases serum magnesium levels at all tested doses, but does not alter brain magnesium levels at any dose, causes a small decrease in muscle magnesium only at the lowest dose, and shows no difference in efficacy between single high-dose and divided high-dose regimens[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (adult, gender not specified)[2]
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Dosage:45 mg/70 kg elemental magnesium; 135 mg/70 kg elemental magnesium; 405 mg/70 kg elemental magnesium; 202.5 mg/70 kg elemental magnesium (total 405 mg/70 kg elemental magnesium)
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Administration:p.o.; single dose
p.o.; two doses 12 hours apart -
Result:Exhibited equivalent brain magnesium concentrations without inter-dose or control-significant disparities.
Recorded reduced muscle magnesium at 45 mg/70 kg (12.5 mg/g tissue, significant vs control), while 135 and 405 mg/70 kg doses (13.5, 12.7 mg/g tissue) matched control levels.
Detected uniformly elevated serum magnesium, all statistically higher than control values.
Measured comparable brain magnesium (6.4 mg/g protein) for split 202.5 mg/70 kg dose relative to control and single high-dose groups.
Captured identical muscle magnesium (13.5 mg/g tissue) for divided dosing versus control and single high-dose cohorts.
Observed elevated serum magnesium (2.8 mg/dL) under split dosing, with no divergence from single high-dose outcomes.
Chemical Information
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No. CAS 869-06-7
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Peso molecular 158.38
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Fòrmula C4H6MgO5
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SMILES
O=C(CC(C(O[Mg])=O)O)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Xu H, et al. Magnesium malate-modified calcium phosphate bone cement promotes the repair of vertebral bone defects in minipigs via regulating CGRP. Journal of nanobiotechnology. 2024 Jun 25;22(1):368. [Content Brief]
[2]. Ates M, et al. Dose-Dependent Absorption Profile of Different Magnesium Compounds. Biological trace element research. 2019 Dec;192(2):244-251. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Magnesium malate Related Classifications
HY-187131 Related Classifications
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