869-06-7
Chemical Structure
Magnesium malate
- CAS. Nr.: 869-06-7
- Formula:C4H6MgO5
- Molecular Weight:158.38
InChIKey: CBZDGXZOWAJNCY-UHFFFAOYSA-M
SMILES: O=C(CC(C(O[Mg])=O)O)O
Biological Activity: Magnesium malate is an orally active organic acid-chelated magnesium complex. Magnesium malate promotes the release of prostaglandin E2 (PGE2) from macrophages, synergistically stimulates the synthesis/release of calcitonin gene-related peptide (CGRP) from dorsal root ganglion neurons, and upregulates the osteogenic transcription factor RUNX2 in osteoblasts via the Mg2+-PGE2-CGRP axis, thereby promoting osteoblast proliferation. Magnesium malate can be incorporated into calcium phosphate bone cement as a modifying component to improve compressive strength, shorten setting time and enhance disintegration resistance. Magnesium malate increases serum magnesium levels. Magnesium malate can be used in studies related to bone defects and magnesium deficiency[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Magnesium malate | Magnesium malate is an orally active organic acid-chelated magnesium complex. Magnesium malate promotes the release of prostaglandin E2 (PGE2) from macrophages, synergistically stimulates the synthesis/release of calcitonin gene-related peptide (CGRP) from dorsal root ganglion neurons, and upregulates the osteogenic transcription factor RUNX2 in osteoblasts via the Mg2+-PGE2-CGRP axis, thereby promoting osteoblast proliferation. Magnesium malate can be incorporated into calcium phosphate bone cement as a modifying component to improve compressive strength, shorten setting time and enhance disintegration resistance. Magnesium malate increases serum magnesium levels. Magnesium malate can be used in studies related to bone defects and magnesium deficiency. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Xu H, et al. Magnesium malate-modified calcium phosphate bone cement promotes the repair of vertebral bone defects in minipigs via regulating CGRP. Journal of nanobiotechnology. 2024 Jun 25;22(1):368. [Content Brief]
- [2]. Ates M, et al. Dose-Dependent Absorption Profile of Different Magnesium Compounds. Biological trace element research. 2019 Dec;192(2):244-251. [Content Brief]
Keywords
