Mandipropamid
Based on 1 Customer Validation
Mandipropamid is a cellulose synthase (CesA3) inhibitor and fungicide, with an IC50 of 19.8 nM against Phytophthora infestans. Mandipropamid inhibits the synthesis of crystalline cellulose on the cell surface, disrupts the cell wall structure of oomycetes, and induces germ tube tip swelling and growth arrest in Phytophthora infestans. S-Mandipropamid, an isomer of Mandipropamid, exhibits enantioselective acute toxicity to zebrafish embryos and larvae. Mandipropamid is applicable to studies related to plant infections.
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- Pureza: 99.58%
- No. CAS: 374726-62-2
- Fòrmula: C23H22ClNO4
- Peso molecular:411.88
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Mandipropamid (MPD) (68 nM; 1-3 h) induces reversible growth arrest and swelling of germ tube tips in germinated Phytophthora infestans sporangia[1].
Mandipropamid (17-68 nM; 6 h) potently inhibits crystalline cellulose synthesis in germinating sporangia of Phytophthora infestans, with an IC50 of 19.8 nM, and this inhibitory effect occurs before detectable changes in glucose uptake or germ tube growth[1].
Mandipropamid (0.01-35 mM; 7 days) causes homozygous EMS mutants Tmut3 and Tmut7 of Phytophthora infestans to exhibit stable high-level insensitivity to Mandipropamid. Specifically, Tmut3 shows unimpaired growth at concentrations up to 35 mM, while expression of the mutant PiCesA3G1105V allele in a wild-type background confers partial insensitivity[1].
Mandipropamid causes the Phytophthora infestans mutant strains Tmut3 and Tmut7 to exhibit a resistance factor of over 1512-fold against its induced inhibition of germ tube length, with their IC50 values exceeding 121 μM, whereas the IC50 value of the wild-type T30-4 strain is 0.08 nM[1].
S-Mandipropamid potently inhibits mycelial growth of Phytophthora capsici, Phytophthora sojae, Phytophthora melonis, Phytophthora nicotianae, Phytophthora infestans and Peronophythora litchii, with EC50 values ranging from 0.007 to 0.021 mg/L[2].
The EC50 of S-Mandipropamid for 7-day growth inhibition of Spirodela polyrhiza is 14.86 mg/L[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 374726-62-2
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Appearance Solid
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Peso molecular 411.88
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Fòrmula C23H22ClNO4
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Color Off-white to light yellow
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SMILES
O=C(C(C1=CC=C(C=C1)Cl)OCC#C)NCCC2=CC=C(C(OC)=C2)OCC#C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 100 mg/mL (242.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (284 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Blum M, et al. Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, Phytophthora infestans. Molecular plant pathology. 2010 Mar;11(2):227-43. [Content Brief]
[2]. Zhang J, et al. Enantioselective Bioactivity, Toxicity, and Degradation in Vegetables and Soil of Chiral Fungicide Mandipropamid. Journal of agricultural and food chemistry. 2021 Nov 17;69(45):13416-13424. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4279 mL | 12.1395 mL | 24.2789 mL | 60.6973 mL |
| 5 mM | 0.4856 mL | 2.4279 mL | 4.8558 mL | 12.1395 mL | |
| 10 mM | 0.2428 mL | 1.2139 mL | 2.4279 mL | 6.0697 mL | |
| 15 mM | 0.1619 mL | 0.8093 mL | 1.6186 mL | 4.0465 mL | |
| 20 mM | 0.1214 mL | 0.6070 mL | 1.2139 mL | 3.0349 mL | |
| 25 mM | 0.0971 mL | 0.4856 mL | 0.9712 mL | 2.4279 mL | |
| 30 mM | 0.0809 mL | 0.4046 mL | 0.8093 mL | 2.0232 mL | |
| 40 mM | 0.0607 mL | 0.3035 mL | 0.6070 mL | 1.5174 mL | |
| 50 mM | 0.0486 mL | 0.2428 mL | 0.4856 mL | 1.2139 mL | |
| 60 mM | 0.0405 mL | 0.2023 mL | 0.4046 mL | 1.0116 mL | |
| 80 mM | 0.0303 mL | 0.1517 mL | 0.3035 mL | 0.7587 mL | |
| 100 mM | 0.0243 mL | 0.1214 mL | 0.2428 mL | 0.6070 mL |
Mandipropamid Related Classifications
HY-W744966 Related Classifications
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