374726-62-2
Chemical Structure
Mandipropamid
- CAS 番号: 374726-62-2
- Formula:C23H22ClNO4
- Molecular Weight:411.88
IUPAC Name: 2-(4-chlorophenyl)-N-(3-methoxy-4-(prop-2-yn-1-yloxy)phenethyl)-2-(prop-2-yn-1-yloxy)acetamide
InChIKey: KWLVWJPJKJMCSH-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=C(C=C1)Cl)OCC#C)NCCC2=CC=C(C(OC)=C2)OCC#C
Biological Activity: Mandipropamid is a cellulose synthase (CesA3) inhibitor and fungicide, with an IC50 of 19.8 nM against Phytophthora infestans. Mandipropamid inhibits the synthesis of crystalline cellulose on the cell surface, disrupts the cell wall structure of oomycetes, and induces germ tube tip swelling and growth arrest in Phytophthora infestans. S-Mandipropamid, an isomer of Mandipropamid, exhibits enantioselective acute toxicity to zebrafish embryos and larvae. Mandipropamid is applicable to studies related to plant infections[1][2].
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Mandipropamid | 99.58% | Mandipropamid is a cellulose synthase (CesA3) inhibitor and fungicide, with an IC50 of 19.8 nM against Phytophthora infestans. Mandipropamid inhibits the synthesis of crystalline cellulose on the cell surface, disrupts the cell wall structure of oomycetes, and induces germ tube tip swelling and growth arrest in Phytophthora infestans. S-Mandipropamid, an isomer of Mandipropamid, exhibits enantioselective acute toxicity to zebrafish embryos and larvae. Mandipropamid is applicable to studies related to plant infections. | ||||||||||||||||||||
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Mandipropamid (Standard) | ≥98% | Mandipropamid (Standard) is the analytical standard of Mandipropamid (HY-W744966). This product is intended for research and analytical applications. Mandipropamid is a cellulose synthase (CesA3) inhibitor and fungicide, with an IC50 of 19.8 nM against Phytophthora infestans. Mandipropamid inhibits the synthesis of crystalline cellulose on the cell surface, disrupts the cell wall structure of oomycetes, and induces germ tube tip swelling and growth arrest in Phytophthora infestans. S-Mandipropamid, an isomer of Mandipropamid, exhibits enantioselective acute toxicity to zebrafish embryos and larvae. Mandipropamid is applicable to studies related to plant infections. | ||||||||||||||||||||
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- [1]. Blum M, et al. Mandipropamid targets the cellulose synthase-like PiCesA3 to inhibit cell wall biosynthesis in the oomycete plant pathogen, Phytophthora infestans. Molecular plant pathology. 2010 Mar;11(2):227-43. [Content Brief]
- [2]. Zhang J, et al. Enantioselective Bioactivity, Toxicity, and Degradation in Vegetables and Soil of Chiral Fungicide Mandipropamid. Journal of agricultural and food chemistry. 2021 Nov 17;69(45):13416-13424. [Content Brief]
