1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Ro 363 hydrochloride

Ro 363 hydrochloride 

Cat. No.: HY-123268A Purity: 95.88%
Handling Instructions

Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility.

For research use only. We do not sell to patients.

Ro 363 hydrochloride Chemical Structure

Ro 363 hydrochloride Chemical Structure

CAS No. : 250580-70-2

Size Price Stock Quantity
10 mg USD 320 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].

In Vitro

Isolated perfused heart preparations from guinea-pigs developed arrhythmic contractions following the administration of Ro 363 in doses producing 70-100% of its maximal chronotropic responses[1].
In spontaneously contracted tracheal preparations from the guinea-pig, RO 363 is a full agonist and is approximately half as potent as (-)-Isoprenaline. These effects of RO 363 are due to the activation of a population of β1-receptors in the tissue since RO 363 and (-)-Isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

399.87

Formula

C₁₉H₂₆ClNO₆

CAS No.
SMILES

OC1=CC=C(OCC(O)CNCCC2=CC=C(OC)C(OC)=C2)C=C1O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (312.60 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5008 mL 12.5041 mL 25.0081 mL
5 mM 0.5002 mL 2.5008 mL 5.0016 mL
10 mM 0.2501 mL 1.2504 mL 2.5008 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Ro 363Ro363Ro-363Adrenergic ReceptorBeta Receptorβ1-adrenoceptorarrhythmogenictrachealpreparationsvasodilator cardiovascularinotropicmyocardialcontractilityInhibitorinhibitorinhibit

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Product Name:
Ro 363 hydrochloride
Cat. No.:
HY-123268A
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