1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Ro 363

Ro 363 

Cat. No.: HY-123268
Handling Instructions

Ro 363 is a potent and highly selective β1-adrenoceptor agonist. RO 363 is an effective inotropic stimulant, and is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility.

For research use only. We do not sell to patients.

Ro 363 Chemical Structure

Ro 363 Chemical Structure

CAS No. : 74513-77-2

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Description

Ro 363 is a potent and highly selective β1-adrenoceptor agonist. RO 363 is an effective inotropic stimulant, and is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].

IC50 & Target

β1-adrenoceptor[1]

In Vitro

Isolated perfused heart preparations from guinea-pigs developed arrhythmic contractions following the administration of Ro 363 in doses producing 70-100% of its maximal chronotropic responses[1].
RO 363 is approximately half as potent as (-)-Isoprenaline in tissues where actions are due to β1-receptor activation (guinea-pig atrial and ileal preparations and ventricular strips from the rabbit, rat and guinea-pig[2].
In spontaneously contracted tracheal preparations from the guinea-pig, RO 363 is a full agonist and is approximately half as potent as (-)-Isoprenaline. These effects of RO 363 are due to the activation of a population of β1-receptors in the tissue since RO 363 and (-)-Isoprenaline have the same relative potencies in trachea, cardiac and ileal preparations[2].

In Vivo

In chloralose-anaesthetized cats, Ro 363, when compared to epinephrine (adrenaline), is essentially devoid of arrhythmogenic activity in animals in which cardiac sensitization is induced by U-0882 or halothane[1].
Ro 363 elicits ventricular arrhythmias following the administration of subarrhythmic doses of ouabain and increases the number of subauricular escape beats which occurred during vagal nerve stimulation in non-ouabain treated animals[1].

Molecular Weight

363.40

Formula

C₁₉H₂₅NO₆

CAS No.

74513-77-2

SMILES

OC1=CC=C(C=C1O)OCC(CNCCC2=CC=C(C(OC)=C2)OC)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ro 363Ro363Ro-363Adrenergic ReceptorBeta Receptorβ1-adrenoceptorarrhythmogenictrachealpreparationsvasodilator cardiovascularinotropicmyocardialcontractilityInhibitorinhibitorinhibit

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Ro 363
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HY-123268
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