Mt KARI-IN-2
Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL).
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- No. CAS: 2413974-52-2
- Fòrmula: C14H11N5O4S2
- Peso molecular:377.40
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Ki: 2.02 μM (Mtb KARI)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
86 μM
Compound: 5b
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 32171154] |
Chemical Information
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No. CAS 2413974-52-2
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Peso molecular 377.40
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Fòrmula C14H11N5O4S2
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SMILES
COC1=CC=C(C=C1)NC(NC2=NN=C(S2)C3=CC=C(O3)[N+]([O-])=O)=S
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mt KARI-IN-2 Related Classifications
HY-146299 Related Classifications
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