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Referencia número: HY-116799

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NSC 145669

NSC 145669 is an inhibitor for tubulin polymerization with IC₅₀ of 1.7 μM. NSC 145669 exhibits cytotoxicity in cancer cells and reveals antileukemic efficacy in mice.

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No. CAS: 31785-60-1
Fòrmula: C₁₈H₁₄N₂O
Peso molecular:274.32

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

NSC 145669 Chemical Structure

No. CAS: 31785-60-1

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Actividad biológica
- Descripciòn
- Cellular Effect
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
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Bioz

Actividad biológica

Descripciòn

NSC 145669 is an inhibitor for tubulin polymerization with IC₅₀ of 1.7 μM. NSC 145669 exhibits cytotoxicity in cancer cells and reveals antileukemic efficacy in mice^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	GI₅₀	0.031 μM Compound: 39	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
A-431	GI₅₀	0.02 μM Compound: 39	Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
BE(2)-C	GI₅₀	0.027 μM Compound: 39	Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
DU-145	GI₅₀	0.089 μM Compound: 39	Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
HT-29	GI₅₀	0.02 μM Compound: 39	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MCF-10A	GI₅₀	0.04 μM Compound: 39	Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MCF7	GI₅₀	0.075 μM Compound: 39	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MIA PaCa-2	GI₅₀	0.048 μM Compound: 39	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
NCI-H460	GI₅₀	0.037 μM Compound: 39	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
U-87MG ATCC	GI₅₀	0.22 μM Compound: 39	Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]

Chemical Information

No. CAS 31785-60-1
Peso molecular 274.32
Fòrmula C₁₈H₁₄N₂O
SMILES

O=C1NC(NC2=C1C=CC=C2)C3=C4C=CC=CC4=CC=C3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Hamel E, et al., Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives. Interactions with tubulin. Biochem Pharmacol. 1996 Jan 12;51(1):53-9. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculadora de dilución

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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