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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
MPL
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "MPL" in MCE Product Catalog:
4
4 Cited Publications
Áreas de investigación:
Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of platelets in mouse xenotransplantation assay .
1
1 Cited Publications
Referencia número: HY-P7088
Pureza: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: THPO; Prepro-Thrombopoietin; Prev. MGDF; MPL Ligand; Myeloproliferative Leukemia Virus Oncogene Ligand; ML; Megakaryocyte Growth And Development Factor; Thrombopoietin Nirs Variant 3; Megakaryocyte Colony-Stimulating Factor; Thrombopoietin Nirs Variant 2
Synonyms: Megakaryocytes/platelets inducing agent
Target:
Áreas de investigación:
TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells .
Referencia número: HY-P990685
No. CAS: 267639-76-9
Target:
Áreas de investigación:
Synonyms: Hetrombopag (tautomerism); SHR-8735 (tautomerism)
Áreas de investigación:
Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Referencia número: HY-145589
No. CAS: 2600513-51-5
Synonyms: Hetrombopag; SHR-8735
Áreas de investigación:
Rafutrombopag (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Referencia número: HY-148748G
No. CAS: 1110767-45-7
Referencia número: HY-RS08616
Target:
Áreas de investigación:
MPL Human Pre-designed siRNA Set A contains three designed siRNAs for MPL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-159671
No. CAS: 252042-59-4
Synonyms: 3D-MPL (14)
Referencia número: HY-112486G
No. CAS: 1429321-13-0
Synonyms: Megakaryocytes/platelets inducing agent (GMP)
Referencia número: HY-NP074
Synonyms: MPL
Referencia número: HY-RS08617
Target:
Áreas de investigación:
Mpl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mpl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS08618
Target:
Áreas de investigación:
Mpl Rat Pre-designed siRNA Set A contains three designed siRNAs for Mpl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-P990469
Synonyms: TA136
Target:
Áreas de investigación:
Referencia número: HY-159671B
Synonyms: 3D-MPL (14) ammonium
Target:
Áreas de investigación:
3D-Monophosphoryl Lipid (14) (3D-MPL (14)) ammonium is a TLR agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
Referencia número: HY-159672A
No. CAS: 220048-49-7
Synonyms: 3D-MPL (12,16) free acid
Target:
Áreas de investigación:
3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) free acid is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
Referencia número: HY-159672B
Synonyms: 3D-MPL (12,16) triethylamine
Target:
Áreas de investigación:
3D-Monophosphoryl Lipid (12,16) (3D-MPL (12,16)) triethylamine is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
Referencia número: HY-125101A
No. CAS: 1257792-42-9
Rafutrombopag (Hetrombopag) diolamine is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag diolamine can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag diolamine specifically stimulates proliferation and differentiation of human TPOR-expressing cells, including 32D-MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag diolamine effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag diolamine protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag diolamine can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .
Referencia número: HY-159671A
No. CAS: 252042-60-7
Synonyms: 3D-MPL (14) triethylamine
Target:
Áreas de investigación:
3D-Monophosphoryl Lipid (14) (3D-Monophosphoryl Lipid (14)) triethylamine is a TLR4 agonist that can be used as a vaccine adjuvant to enhance the immunogenicity of vaccines .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
