2. Gene
  3. Mir223 - microRNA 223 Gene

Mir223 - microRNA 223 Gene

  • Gene
  • Agent
  • Ortholog
Rattus norvegicus

Also known as rno-mir-223

Gene ID: 100314060 | Gene type: ncRNA

About Mir223

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
29608885 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
29707878 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
23046980 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
29689569 RGD
involved in negative regulation of autophagy IDA
IDA: Inferred from direct assay
29608885 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IDA
IDA: Inferred from direct assay
29608885 RGD
involved in negative regulation of cell size IDA
IDA: Inferred from direct assay
29110214 RGD
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
31237865 RGD
involved in negative regulation of interleukin-18 production IMP
IMP: Inferred from mutant phenotype
31237865 RGD
involved in negative regulation of vascular associated smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
30246291 RGD
involved in physiological cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
27226563 RGD
involved in positive regulation of fibroblast chemotaxis IMP
IMP: Inferred from mutant phenotype
29689569 RGD
involved in positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
29689569 RGD
involved in positive regulation of myofibroblast differentiation IMP
IMP: Inferred from mutant phenotype
29689569 RGD
involved in response to gravity IEP
IEP: Inferred from expression pattern
28642576 RGD
involved in response to psychosocial stress IEP
IEP: Inferred from expression pattern
31339402 RGD
Cellular Component GO Annotation Evidence Reference Source
located in blood microparticle IDA
IDA: Inferred from direct assay
26065992 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (17)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W176171 PU.1-IN-1 Inhibitor 99.72% Unkown
HY-R00467 hsa-miR-223-3p mimic 98.07% Unkown
HY-R00467A hsa-miR-223-3p agomir 97.24% Unkown
HY-RI00467 hsa-miR-223-3p inhibitor 98.66% Unkown
HY-RI00467A hsa-miR-223-3p antagomir 95.82% Unkown
HY-R00468 hsa-miR-223-5p mimic / Unkown
HY-R00468A hsa-miR-223-5p agomir / Unkown
HY-R02848 mmu-miR-223-5p mimic / Unkown
HY-R02848A mmu-miR-223-5p agomir / Unkown
HY-R04313 rno-miR-223-3p mimic / Unkown
HY-R04313A rno-miR-223-3p agomir / Unkown
HY-RI00468 hsa-miR-223-5p inhibitor / Unkown
HY-RI00468A hsa-miR-223-5p antagomir / Unkown
HY-RI02848 mmu-miR-223-5p inhibitor / Unkown
HY-RI02848A mmu-miR-223-5p antagomir / Unkown
HY-RI04313 rno-miR-223-3p inhibitor / Unkown
HY-RI04313A rno-miR-223-3p antagomir 99.03% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir223 NCBI NCBI:407008