MIR223 - microRNA 223 Gene
Also Known as MIRN223; mir-223; miRNA223
Species: Homo sapiens
About MIR223
This gene has 1 transcript (splice variant) and 81 orthologues.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables lncRNA binding |
IDA
IDA: Inferred from direct assay
|
31525642 | GOA |
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
34637033 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
23459944 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in extracellular exosome |
IDA
IDA: Inferred from direct assay
|
31926946 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
26646931 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neutrophilia, Hereditary |
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| Leukemia, Chronic Myeloid |
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| Acute Promyelocytic Leukemia |
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| Hepatocellular Carcinoma |
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| Ovarian Cancer |
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| Primary Biliary Cholangitis |
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| Dermatomyositis |
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| Multiple Sclerosis |
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| Inclusion Body Myositis |
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| Sezary'S Disease |
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| Essential Thrombocythemia |
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| Myelofibrosis |
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| Leukemia, Acute Lymphoblastic |
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| Miyoshi Muscular Dystrophy 1 |
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| Endometriosis |
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| Pituitary Adenoma |
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| Systemic Lupus Erythematosus |
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| Vulva Cancer |
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| Nemaline Myopathy |
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| Esophageal Cancer |
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| Oral Squamous Cell Carcinoma |
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| Leukemia, Chronic Lymphocytic |
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| Pancreatic Ductal Adenocarcinoma |
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| Leukemia, Acute Myeloid |
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| Vulvar Disease |
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| Pancreatic Cancer |
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| Bladder Cancer |
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| Prostate Cancer |
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| Buerger Disease |
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| Gastric Cancer |
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| Colorectal Cancer |
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| Bone Inflammation Disease |
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| Arteries, Anomalies Of |
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| Chorioamnionitis |
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| Extrinsic Cardiomyopathy |
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| Autoimmune Disease Of Musculoskeletal System |
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| Autoimmune Disease Of Central Nervous System |
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| Glucose Metabolism Disease |
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| Carbohydrate Metabolic Disorder |
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| Autoimmune Disease Of Gastrointestinal Tract |
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| Inherited Metabolic Disorder |
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| Immune System Disease |
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| Endometrial Disease |
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| Respiratory System Disease |
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| Human Papillomavirus Infectious Disease |
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| Acquired Metabolic Disease |
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| Pleural Cancer |
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| Esophageal Disease |
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| Chromosomal Deletion Syndrome |
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| Atrial Fibrillation |
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| Heart Conduction Disease |
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| Aortic Disease |
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| Bone Resorption Disease |
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| Female Reproductive System Disease |
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| Overnutrition |
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| Stomach Disease |
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| Potocki-Shaffer Syndrome |
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| Respiratory System Cancer |
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| Lymph Node Disease |
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| Bone Remodeling Disease |
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| Pleural Disease |
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| Penile Cancer |
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| Autoimmune Disease Of Skin And Connective Tissue |
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| Aortic Valve Insufficiency |
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| Gastrointestinal System Disease |
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| Lymphatic System Disease |
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| Myocardial Infarction |
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| Pneumonia |
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| Central Nervous System Disease |
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| Primary Bacterial Infectious Disease |
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| Lymphatic System Cancer |
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| Intestinal Disease |
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| Nodular Goiter |
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| Connective Tissue Cancer |
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| Spinal Disease |
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| Urinary System Disease |
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| Bronchial Disease |
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| Disease By Infectious Agent |
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| Lipoprotein Quantitative Trait Locus |
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| Integumentary System Disease |
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| Sensory System Disease |
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| Reproductive System Disease |
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| Complex Regional Pain Syndrome |
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| Gastrointestinal System Cancer |
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| Ovarian Disease |
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| Chromosomal Disease |
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| Endometritis |
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| Endocrine System Disease |
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| Nasopharyngeal Carcinoma |
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| Demyelinating Disease |
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| Bone Structure Disease |
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| Bone Sarcoma |
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| Thoracic Cancer |
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| Bone Deterioration Disease |
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| Cerebrovascular Disease |
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| Malignant Astrocytoma |
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| Nasopharyngeal Disease |
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| Lung Cancer |
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| Large Intestine Cancer |
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| Endocrine Gland Cancer |
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| Uterine Anomalies |
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| Central Nervous System Cancer |
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| Upper Respiratory Tract Disease |
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| Lymphadenitis |
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| Degenerative Disc Disease |
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| Disease Of Mental Health |
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| Diabetes Mellitus |
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| Pharynx Cancer |
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| Bone Cancer |
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| Hematologic Cancer |
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| Male Reproductive System Disease |
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| Hypertension, Essential |
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| Male Reproductive Organ Cancer |
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| Intrinsic Cardiomyopathy |
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| Pancreas Disease |
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| Connective Tissue Disease |
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| Placenta Disease |
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| Cardiovascular System Disease |
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| Breast Disease |
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| Malignant Exocrine Pancreas Neoplasm |
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| Bone Disease |
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| Bladder Disease |
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| Cervix Disease |
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| Prostate Disease |
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| Oral Cavity Cancer |
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| Interstitial Lung Disease |
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| Pulmonary Disease, Chronic Obstructive |
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| Aortic Dissection |
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| Nervous System Disease |
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| Colonic Disease |
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| Retinal Disease |
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| Mycobacterium Tuberculosis 1 |
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| Lung Squamous Cell Carcinoma |
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| Immune Deficiency Disease |
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| Asthma |
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| Eye Disease |
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| Lipid Metabolism Disorder |
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| Lymphoma, Non-Hodgkin, Familial |
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| Heart Disease |
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| T-Cell Acute Lymphoblastic Leukemia |
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| Skin Disease |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Renal Cell Carcinoma, Nonpapillary |
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| Hypertrophic Cardiomyopathy |
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| Type 2 Diabetes Mellitus |
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| Alzheimer Disease, Familial, 1 |
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| Parkinson Disease, Late-Onset |
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