2. Stem Cell/Wnt TGF-beta/Smad MAPK/ERK Pathway
  3. TGF-beta/Smad p38 MAPK
  4. Klotho-derived peptide 1 hydrochloride

Klotho-derived peptide 1 hydrochloride  (Synonyms: KP1 (human) hydrochloride)

Cat. No.: HY-P10414A Pureza: 99.67%
COA
SDS
Instrucciones de manejo Technical Support

Klotho-derived peptide 1 (KP1 human) hydrochloride blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model.

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Klotho-derived peptide 1 hydrochloride

Klotho-derived peptide 1 hydrochloride Estructura química

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Other Forms of Klotho-derived peptide 1 hydrochloride:

Klotho-derived peptide 1 hydrochloride Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas p38 MAPK:

Ver todas las isoformas
p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Descripciòn

Klotho-derived peptide 1 (KP1 human) hydrochloride blocks TGF-β/TGF-β receptor 2 interaction, inhibits TGF-β-induced activation of Smad2/3 and mitogen-activated protein kinase (MAPK), and exhibits anti-fibrotic and kidney protective effects in mouse model[1].

Peso molecular

3228.44 (free base)

Fòrmula

C149H203N39O43.xHCl
Appearance

Solid

Color

White to off-white

Sequence

Phe-Gln-Gly-Thr-Phe-Pro-Asp-Gly-Phe-Leu-Trp-Ala-Val-Gly-Ser-Ala-Ala-Tyr-Gln-Thr-Glu-Gly-Gly-Trp-Gln-Gln-His-Gly-Lys-Gly
Sequence Shortening

FQGTFPDGFLWAVGSAAYQTEGGWQQHGKG
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

0.1 M Acetic acid : 50 mg/mL (adjust pH to 2 with CH3COOH)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 99.67%

SDS (252 KB)

COA (258 KB) LCMS (85 KB) Elemental Analysis Report (117 KB)

Instrucciones de manejo (2659 KB)
Referencias
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Klotho-derived peptide 1 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Klotho-derived peptide 1KP1 (human)TGF-beta/Smadp38 MAPKTransforming growth factor betaNRK-49Frenal fibrosisBALB/c mouseUIRIUUOInhibitorinhibitorinhibit

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Nombre del producto:
Klotho-derived peptide 1 hydrochloride
Cat. No.:
HY-P10414A
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