PREB - prolactin regulatory element binding Gene

Also Known as SEC12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10113

About PREB

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,130,756-27,134,636 (from NCBI)

This gene has 9 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in ovary (RPKM 22.2), fat (RPKM 20.3) and 25 other tissues.

Summary

This gene encodes a protein that specifically binds to a Pit1-binding element of the Prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand. [provided by RefSeq, Jul 2008]

PREB Products (5)

mRNA Protein Name
NM_001330484.2 NP_001317413.1 prolactin regulatory element-binding protein isoform 2
NM_001330485.2 NP_001317414.1 prolactin regulatory element-binding protein isoform 3
NM_001330486.2 NP_001317415.1 prolactin regulatory element-binding protein isoform 4
NM_001330487.2 NP_001317416.1 prolactin regulatory element-binding protein isoform 5
NM_013388.6 NP_037520.1 prolactin regulatory element-binding protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
32358066 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25202031 GOA
Biological Process GO Annotation Evidence References Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IDA
IDA: Inferred from direct assay
32358066 GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
25202031 GOA
involved in regulation of COPII vesicle coating IDA
IDA: Inferred from direct assay
32358066 GOA
Cellular Component GO Annotation Evidence References Source
is active in endoplasmic reticulum exit site IDA
IDA: Inferred from direct assay
25202031 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10194769 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PREB Protein Structure

WD40

WD40: WD domain, G-beta repeat (160 - 182)

WD40

WD40: WD domain, G-beta repeat (188 - 222)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
Protein Preferred Names Protein Names

prolactin regulatory element-binding protein

  • mammalian guanine nucleotide exchange factor mSec12

PREB Antibodies

Cat. No. Product Name Application Reactivity
HY-P81984 PREB Antibody (YA1729) WB, IHC-P, ICC/IF, IP Human
HY-P81984A PREB Antibody (YA1729)(PBS only) WB, IHC-P, ICC/IF, IP Human

Related Diseases

Diseases Alias
Craniolenticulosutural Dysplasia

  • Boyadjiev-Jabs Syndrome

  • CLSD

  • Cranio-Lenticulo-Sutural Dysplasia

  • Cranio-Lenticulo-Sutural Dysplasia, Clsd
Chylomicron Retention Disease

  • CMRD

  • Anderson Disease

  • Lipid Transport Defect Of Intestine

  • Hypobetalipoproteinemia With Accumulation Of Apolipoprotein B-Like Protein In Intestinal Cells

  • Andd

  • Anderson Syndrome

  • Crd

  • Andersons Disease

  • Malabsorption Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70016 Terminal deoxyribonucleotidyltransferase Inhibitor / Unkown
HY-116170 SN34037 Inhibitor 99.02% Unkown
HY-RS11080 PREB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N16567 Acrofolione A / Unkown
HY-RS22286 Preb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28809 Preb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PREB MGD MGI:1355326
Bos taurus PREB VGNC VGNC:33305
Felis catus PREB VGNC VGNC:69039
Canis familiaris PREB VGNC VGNC:44954
Macaca mulatta PREB VGNC VGNC:103847
Rattus norvegicus PREB RGD RGD:61929
Others PREB NCBI