NUDC - nuclear distribution C, dynein complex regulator Gene

Also Known as HNUDC; MNUDC; NPD011

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10726

About NUDC

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,900,161-26,946,871 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 27.7), adrenal (RPKM 27.5) and 25 other tissues.

Summary

This gene encodes a nuclear distribution protein that plays an essential role in Mitosis and cytokinesis. The encoded protein is involved in spindle formation during Mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

NUDC Products (1)

mRNA Protein Name
NM_006600.4 NP_006591.1 nuclear migration protein nudC

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
22159412 GOA
Biological Process GO Annotation Evidence Références Source
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
25789526 GOA
involved in mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
25789526 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25468996 GOA
located in midbody IDA
IDA: Inferred from direct assay
25789526 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
25789526 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDC Protein Structure

Nudc_N

Nudc_N: N-terminal conserved domain of Nudc. (8 - 60)

CS

CS: CS domain (170 - 247)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
Protein Preferred Names Protein Names

nuclear migration protein nudC

  • nuclear distribution C homolog

NUDC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NUDC Q9Y266 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
NUDC Q9Y266 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
NUDC Q9Y266 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
NUDC Q9Y266 DYNC2I1 Homo sapiens Q8WVS4
TAP
27173435
Intra
NUDC Q9Y266 POC1A Homo sapiens Q8NBT0
Lumier
25036637
Intra
NUDC Q9Y266 GIPC1 Homo sapiens O14908-2
Y2H Array
32814053
Intra
NUDC Q9Y266 GIPC1 Homo sapiens O14908-2
Y2H Pooling
32814053
Intra
NUDC Q9Y266 GIPC1 Homo sapiens O14908-2
Validated Y2H
32814053
Intra
NUDC Q9Y266 DNAJA2 Homo sapiens O60884
Lumier
25036637
Intra
NUDC Q9Y266 DNAJA2 Homo sapiens O60884
Anti Tag CoIP
25036637
Intra
NUDC Q9Y266 EML1 Homo sapiens O00423
Lumier
25036637
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NUDC Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75947 NUDC Protein, Human (HEK293, His) Q9Y266 (M1-N331) ≥ 95%, as determined by reducing SDS-PAGE.

NUDC Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82626 NUDC Antibody (YA2371) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
3mc Syndrome 1

  • Oculopalatoskeletal Syndrome

  • 3MC1

  • Craniosynostosis With Lid Anomalies

  • Michels Syndrome, Formerly

  • Michels Syndrome

  • 3mc Syndrome, Type 1
Hermansky-Pudlak Syndrome 3

  • HPS3

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 3

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Lissencephaly 1

  • LIS1

  • Classic Lissencephaly

  • Ils

  • Subcortical Laminar Heterotopia

  • Lissencephaly Due To Lis1 Mutation

  • Lissencephaly Sequence, Isolated

  • Lissencephaly, Classic

  • Pafah1b1-Related Lissencephaly

  • Classical Lissencephaly

  • Lissencephaly Type 1

  • Lissencephaly-1

  • Subcortical Band Heterotopia

  • Double Cortex

  • Lissencephaly Classic

  • Lissencephaly Sequence Isolated

  • Isolated Lissencephaly Sequence

  • Type 1 Lissencephaly

  • Lissencephaly Syndrome Type 1

  • SBH

  • Sclh

  • Lissencephaly, Type 1

  • Type I Lissencephaly
Miller-Dieker Lissencephaly Syndrome

  • Miller-Dieker Syndrome

  • Mds

  • MDLS

  • Miller Dieker Syndrome

  • Classical Lissencephaly Syndrome

  • Lissencephaly Due To 17p13.3 Deletion

  • Monosomy 17p13.3

  • Telomeric Deletion 17p

  • Classical Lissencephaly
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09657 NUDC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20315 Nudc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26823 Nudc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NUDC VGNC VGNC:68588
Macaca mulatta NUDC VGNC VGNC:100021
Mus musculus NUDC MGD MGI:106014
Rattus norvegicus NUDC RGD RGD:3215
Canis familiaris NUDC VGNC VGNC:44021
Bos taurus NUDC VGNC VGNC:32321
Others NUDC NCBI