NUDC Antibody (YA2371)
(Synonyms: HNUDC; MNUDC; NPD011; nudC; SIG92)NUDC Antibody (YA2371) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NUDC.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, IP, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS(pH 7.4) containing 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IP
IP: Immunoprecipitation
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FC
FC: Flow Cytometry
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:200 | 1:50 | 1:50-1:100 |
Product Details
NUDC Antibody (YA2371) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NUDC.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 42 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 38 kDa
Entrez Gene: 10726 Human ; 18221 Mouse ; 29648 Rat
SwissProt: Q9Y266 Human ; O35685 Mouse ; Q63525 Rat
OMIM: 610325 Human
A synthesized peptide derived from human NUDC aa280-331/331.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH 7.4) containing 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NUDC plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation[1][2][3].
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Subcellular Localization
Cytoplasm, cytoskeleton; Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody
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Expression
Tissue_specificity:Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in human pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart
Induction:Up-regulated in actively dividing hematopoietic precursor cells. Up-regulated in cultured erythroleukemia TF-1 cells by granulocyte-macrophage colony-stimulating factor. Strongly down-regulated during maturation of erythroid precursor cells -
Subunit
Interacts with PAFAH1B1 (By similarity). Interacts with PLK1 (PubMed:12852857). Part of a complex containing PLK1, NUDC, dynein and dynactin (PubMed:12852857). Interacts with DCDC1 (PubMed:22159412). Interacts with EML4 (via WD repeats) (PubMed:25789526)
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SwissProt ID
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Synonyms
HNUDC; MNUDC; NPD011; nudC; SIG92
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Research Field
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Documentation
References
[1]. Aumais JP, et al. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. J Cell Sci. 2003 May 15;116(Pt 10):1991-2003. [Content Brief]
[2]. Zhou T, et al. A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell. 2003 Jul;5(1):127-38. [Content Brief]
[3]. Chen D, et al. EML4 promotes the loading of NUDC to the spindle for mitotic progression. Cell Cycle. 2015;14(10):1529-39. [Content Brief]
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