PPARGC1A - PPARG coactivator 1 alpha Gene

Also Known as LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10891

About PPARGC1A

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:23,792,021-24,472,905 (from NCBI)

This gene has 18 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 8.0), liver (RPKM 6.2) and 15 other tissues.

Summary

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular Cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

PPARGC1A Products (29)

mRNA	Protein	Name
NR_148985.2
XM_011513768.2	XP_011512070.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4
XM_011513771.2	XP_011512073.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X9
XM_005248131.6	XP_005248188.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1
NR_148981.2
XM_005248134.5	XP_005248191.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X5
NM_001330753.2	NP_001317682.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 4
XM_011513769.3	XP_011512071.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X7
XM_047449552.1	XP_047305508.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X8
XM_047449553.1	XP_047305509.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X9
XM_047449546.1	XP_047305502.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3
XM_047449548.1	XP_047305504.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4
NR_148983.2
XM_047449547.1	XP_047305503.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4
NM_013261.5	NP_037393.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 2
XM_005248132.1	XP_005248189.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X2
NR_148982.2
NM_001354826.2	NP_001341755.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 4
NM_001354827.2	NP_001341756.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 5
NM_001330752.2	NP_001317681.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 3
NR_148984.2
XM_047449550.1	XP_047305506.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4
NM_001354828.2	NP_001341757.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 6
XM_047449551.1	XP_047305507.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X6
NM_001354825.2	NP_001341754.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 1
NR_148986.2
XM_047449549.1	XP_047305505.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X4
NR_148987.2
NM_001330751.2	NP_001317680.1	peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	18798693	GOA
enables nuclear receptor coactivator activity	IDA IDA: Inferred from direct assay	16488887	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12522104	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23836911	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16753578	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	22064484	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in gluconeogenesis	IDA IDA: Inferred from direct assay	16753578	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	25118933	GOA
acts upstream of negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	29182484	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19651776	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16488887	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	23525105	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	29182484	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21376232	GOA
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	27471003	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	23836911	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	10713165	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23836911	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPARGC1A Protein Structure

RRM_1

0
200
400
600
798 a.a.

Protein Preferred Names	Protein Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha	L-PGC-1alpha PGC-1-alpha PPAR gamma coactivator variant form PPARAGCIalpha PPARGC-1-alpha PPARgamma coactivator 1alpha ligand effect modulator-6

PPARGC1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPARGC1A	Q9UBK2	LRPPRC	Homo sapiens	P42704	Anti Bait CoIP	17050673
Intra	PPARGC1A	Q9UBK2	LRPPRC	Homo sapiens	P42704	Anti Tag CoIP	17050673
Intra	PPARGC1A	Q9UBK2	ESRRG	Homo sapiens	P62508	SPR	19914244
Intra	PPARGC1A	Q9UBK2	ESRRG	Homo sapiens	P62508	SPR	19171140
Intra	PPARGC1A	Q9UBK2	ESRRA	Homo sapiens	P11474	Gal4 VP16 Complement	18441008
Intra	PPARGC1A	Q9UBK2	PPARG	Homo sapiens	P37231	Pull Down	19846556

Cross: Cross-species interaction Intra: Intraspecies interaction

PPARGC1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80783	PGC1 alpha Antibody	WB	Human, Mouse, Rat
HY-P80783A	PGC1 alpha Antibody (YA7180)	WB	Human, Mouse, Rat
HY-P80783AA	PGC1 alpha Antibody (YA7180)(PBS only)	WB	Human, Mouse, Rat
HY-P83728	PGC1 alpha+beta Antibody (YA3458)	WB	Human, Mouse, Rat
HY-P85326	PGC1 alpha Antibody (YA5018)	WB	Mouse, Rat

Related Diseases

Diseases	Alias
Muscle Tissue Disease
Hyperglycemia
Glucose Metabolism Disease	Glucose Metabolism Disorders Disorder Of Glucose Metabolism
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy, Hypertrophic, Familial Familial Hypertrophic Cardiomyopathy Cardiomyopathy Hypertrophic Obstructive Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Fatty Liver Disease	Alcoholic Fatty Liver Fatty Liver Fatty Liver, Alcoholic Fatty Change Of Liver Hepatic Lipidosis Steatosis Of Liver Fatty Liver Alcoholic Steatohepatitis Etoh Fatty Liver Etoh Fatty Liver Metamorphosis Fatty Etoh Liver Necrosis
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Myopathy	Muscular Diseases Myopathies
Acquired Metabolic Disease
Overnutrition
Friedreich Ataxia	Friedreich Ataxia 1 FRDA Friedreich Ataxia With Retained Reflexes Frda1 Fa Friedreich'S Ataxia Hereditary Spinal Ataxia Fa1 Friedreich'S Tabes Hereditary Spinal Sclerosis Spinocerebellar Ataxia, Friedreich Friedreich Spinocerebellar Ataxia Friedrich'S Ataxia
Aging
Huntington Disease	Huntington'S Disease Huntington Chorea HD Huntington'S Chorea Huntington Chronic Progressive Hereditary Chorea Juvenile Huntington Disease Chronic Progressive Chorea Chronic Progressive Hereditary Chorea Hc - [Huntington Chorea] Hereditary Chorea Progressive Hereditary Chorea
Muscular Disease
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	MELAS Melas Syndrome Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Porphyria	Hematoporphyria Porphyrias Disorder Of Porphyrin And Hem Metabolism Disorder Of Porphyrin Metabolism Porphyrinopathy Porphyrin Disorder Disorder Of Porphyrin And Heme Metabolism Disorders Of Porphyrin Metabolism
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Diabetes Mellitus	Diabetes
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Non-Alcoholic Fatty Liver Disease	Fatty Liver Non-Alcoholic Fatty Liver Nafld Nonalcoholic Fatty Liver Disease Nonalcoholic Steatohepatitis Steatosis Nafl Nash Non-Alcoholic Steatohepatitis Susceptibility To Nonalcoholic Fatty Liver Disease Steatohepatitis Fatty Degeneration Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis Nafld Without Nash Nafld Without Mention Of Nash
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Mitochondrial Myopathy	Mitochondrial Myopathies Mitochondrial Cytopathy Myopathies In Mitochondrial Disorders
Lipomatosis	Benign Symmetrical Lipomatosis
Lipid Storage Disease	Lipoidosis Inborn Lipid Storage Disorder Lipoid Storage Diseas Lipid Storage Diseases Lipidoses
Leber Hereditary Optic Neuropathy, Modifier Of	Leber Optic Atrophy Leber Hereditary Optic Neuropathy LHON Leber Optic Atrophy, Susceptibility To Leber'S Hereditary Optic Neuropathy Leber'S Optic Atrophy LOAM Loas Leber'S Disease Leber'S Optic Neuropathy Optic Atrophy, Hereditary, Leber Lhon, Modifier Of Optic Atrophy, Leber Type Hereditary Optic Neuroretinopathy Leber Hereditary Optic Atrophy Loa Optic Atrophy Leber Type Leber Hereditary Optic Neuropathy, Modifier Leber Hereditary Optic Neuropathy Susceptibility Modifier Of Leber Hereditary Optic Neuropathy Lebers Hereditary Optic Neuropathy Atrophy, Optic, Leber'S Leber Congenital Amaurosis
Carbohydrate Metabolic Disorder	Inborn Errors Of Carbohydrate Metabolism Disorder Of Carbohydrate Metabolism Carbohydrate Metabolism, Inborn Errors Disorder Of Carbohydrate Transport And Metabolism Inborn Carbohydrate Metabolism Disorder Inborn Carbohydrate Metabolic Disorder Carbohydrate Metabolism Disorder Carbohydrate Metabolism Disorders Disorders Of Carbohydrate Metabolism Congenital Disorders Of Carbohydrate Metabolism Inherited Disorders Of Carbohydrate Metabolism
Prediabetes Syndrome	Impaired Glucose Tolerance Prediabetes Prediabetic State IGT Igt - [Impaired Glucose Tolerance] Impaired Glucose Tolerance With Unspecified Complication Impaired Glucose Tolerance Without Complication Abnormal Glucose Tolerance
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction Leptin
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10930	Ppargc1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10928	PPARGC1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10929	Ppargc1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PPARGC1A	MGD	MGI:1342774
Bos taurus	PPARGC1A	VGNC	VGNC:33184
Felis catus	PPARGC1A	VGNC	VGNC:68978
Canis familiaris	PPARGC1A	VGNC	VGNC:44837
Macaca mulatta	PPARGC1A	VGNC	VGNC:76230
Rattus norvegicus	PPARGC1A	RGD	RGD:620925
Others	PPARGC1A	NCBI